{"id":"W3007491292","doi":"10.1101/2020.02.20.958363","title":"LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Faculty of Medicine and Health, University of Sydney; Helse Sør-Øst RHF; Helse Midt-Norge; Novo Nordisk; Universitetet i Oslo; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Genomics; Ontario Ministry of Research, Innovation and Science; Norwegian Sequencing Centre; Novartis Pharma; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Novo Nordisk Fonden; Norges Forskningsråd; Kreftforeningen; European Commission; Pfizer","keywords":"Paneth cell; Intestinal epithelium; Epithelium; Biology; Cell biology; Wnt signaling pathway; Organoid; Stem cell; Demethylase; Embryonic stem cell; Intestinal mucosa; Homeostasis; Gene; Epigenetics; Small intestine; Genetics; Internal medicine; Endocrinology; Medicine; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002001209,0.000221981,0.0002575527,0.0002473104,0.0001106006,0.0002290361,0.0001949367,0.0001859016,0.003167064],"category_scores_gemma":[0.0001082031,0.0001261683,0.0001741356,0.0001070419,0.000214323,0.0001278356,0.0002220752,0.0003309128,0.0006266605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003030104,"about_ca_system_score_gemma":0.0002224641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000355553,"about_ca_topic_score_gemma":0.000469783,"domain_scores_codex":[0.9999124,0.00001196185,0.000008988196,0.0000231809,0.00002641571,0.00001703074],"domain_scores_gemma":[0.9998944,0.00001863055,0.00003050302,0.00001473654,0.00001277772,0.00002897179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008158686,0.00000605293,0.000243896,0.00003453795,0.000002190861,0.00002060835,0.000005000733,0.0000520536,0.9983943,0.00004170794,0.00003530978,0.00108266],"study_design_scores_gemma":[0.000004533651,0.00007690763,0.002394934,0.000003093336,0.000004814218,0.00005644929,0.00000881802,0.0001750116,0.9960156,0.00001705784,0.001241133,0.000001579706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849428,0.003674041,0.006345089,0.0001911617,0.00003907376,0.00003042554,0.001802529,0.0003198652,0.002655014],"genre_scores_gemma":[0.9881534,0.001274737,0.003377625,0.00007895152,0.000008352389,0.00003157731,0.001382904,0.00005880578,0.005633674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003167064,"threshold_uncertainty_score":0.0105949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01513075068934504,"score_gpt":0.2572019955281268,"score_spread":0.2420712448387818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}