{"id":"W3007522902","doi":"10.1523/jneurosci.2370-19.2020","title":"Interneuron Desynchronization Precedes Seizures in a Mouse Model of Dravet Syndrome","year":2020,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"National Institute of Neurological Disorders and Stroke; Northwestern University; Dana Foundation; Burroughs Wellcome Fund; Howard Hughes Medical Institute; National Institutes of Health; National Science Foundation","keywords":"Dravet syndrome; Epilepsy; Interneuron; Ictal; Neuroscience; Neocortex; Wakefulness; Parvalbumin; GABAergic; Calcium imaging; Medicine; Biology; Internal medicine; Electroencephalography; Calcium; Inhibitory postsynaptic potential","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003694155,0.001010564,0.0006284994,0.001402337,0.0002810672,0.0004271546,0.0005703331,0.001029148,0.002017253],"category_scores_gemma":[0.0004153112,0.0004792744,0.0005220427,0.0003865112,0.0007718634,0.0004644438,0.0004221357,0.001694249,0.0005060276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006966694,"about_ca_system_score_gemma":0.0004000362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001108913,"about_ca_topic_score_gemma":0.002821455,"domain_scores_codex":[0.9993109,0.0001316092,0.00009105719,0.0002193561,0.0001569961,0.0000902129],"domain_scores_gemma":[0.9991733,0.00008012855,0.0004237236,0.00007023654,0.0000430275,0.0002095387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003600623,0.0001236872,0.000551614,0.0000475386,0.00001771011,0.0003854384,0.00005540991,0.0001435855,0.996752,0.000232318,0.0001320315,0.00119864],"study_design_scores_gemma":[0.0005658012,0.003262878,0.03531553,0.00007538371,0.0001268607,0.004853469,0.0002445406,0.005685529,0.9451811,0.0006134555,0.004022998,0.00005244644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918646,0.0007508526,0.003611049,0.0005124429,0.00006994008,0.0001388852,0.001600381,0.0003606607,0.001091058],"genre_scores_gemma":[0.9872617,0.001004655,0.005479937,0.0002585509,0.00002979556,0.000399904,0.001227833,0.0001756694,0.004161926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002017253,"threshold_uncertainty_score":0.006748378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1121646301103121,"score_gpt":0.3537077327679963,"score_spread":0.2415431026576841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}