{"id":"W3007590143","doi":"10.1172/jci131254","title":"Protein arginine methyltransferase 5 promotes cholesterol biosynthesis–mediated Th17 responses and autoimmunity","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Research Institute, Nationwide Children's Hospital; National Cancer Institute; National Institutes of Health; Nationwide Children's Hospital; Pelotonia; Ohio State University","keywords":"Protein arginine methyltransferase 5; Experimental autoimmune encephalomyelitis; RAR-related orphan receptor gamma; Orphan receptor; Arginine; Cell biology; Biology; Chemistry; Methyltransferase; Biochemistry; Immunology; Immune system; Methylation; FOXP3; Transcription factor; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002113468,0.0002551428,0.0001876462,0.0002883576,0.000162877,0.000323205,0.0001149455,0.0002467285,0.001660954],"category_scores_gemma":[0.0001301669,0.0001104438,0.0002384573,0.0001453423,0.0002552248,0.0001434716,0.0002357916,0.0005399454,0.0003574476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002494179,"about_ca_system_score_gemma":0.0002703198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003803714,"about_ca_topic_score_gemma":0.0007676946,"domain_scores_codex":[0.9997873,0.00004975395,0.00001828522,0.00003464027,0.00004945323,0.00006066271],"domain_scores_gemma":[0.9998825,0.00001012421,0.00004220324,0.00001235424,0.00001190496,0.00004090271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002702396,0.00003621135,0.0008236861,0.00004200638,0.000005450136,0.00008183999,0.00001985896,0.00004496847,0.9957949,0.0001292561,0.0000462389,0.002705266],"study_design_scores_gemma":[0.0000627565,0.0009380796,0.02472001,0.00001883731,0.00004175679,0.000608455,0.00007989333,0.0008788506,0.965265,0.0001780246,0.007201143,0.0000071442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913512,0.003830576,0.001970986,0.0001768907,0.00005076003,0.00002494255,0.0001280113,0.0001064709,0.002360121],"genre_scores_gemma":[0.9965777,0.0007238742,0.0007004353,0.00003941343,0.00001344306,0.00000909459,0.00009067938,0.000007708871,0.001837721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001660954,"threshold_uncertainty_score":0.005556405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06269572043454023,"score_gpt":0.3379813092249564,"score_spread":0.2752855887904162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}