{"id":"W3007590143","doi":"10.1172/jci131254","title":"Protein arginine methyltransferase 5 promotes cholesterol biosynthesis–mediated Th17 responses and autoimmunity","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Research Institute, Nationwide Children's Hospital; National Cancer Institute; National Institutes of Health; Nationwide Children's Hospital; Pelotonia; Ohio State University","keywords":"Protein arginine methyltransferase 5; Experimental autoimmune encephalomyelitis; RAR-related orphan receptor gamma; Orphan receptor; Arginine; Cell biology; Biology; Chemistry; Methyltransferase; Biochemistry; Immunology; Immune system; Methylation; FOXP3; Transcription factor; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001330375,0.0001242009,0.0002930622,0.00004901079,0.00005105052,0.00003054839,0.0001219714,0.0002440118,0.000009935733],"category_scores_gemma":[0.00522258,0.0001060017,0.0001226075,0.0001317355,0.000234322,0.00002115162,0.00003192578,0.0003271728,0.000002893122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000865345,"about_ca_system_score_gemma":0.0002612789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005078755,"about_ca_topic_score_gemma":0.00000488301,"domain_scores_codex":[0.9979928,0.0005903681,0.0009271787,0.0001884008,0.0001932759,0.0001079926],"domain_scores_gemma":[0.9986812,0.0001697487,0.0005379359,0.0001409056,0.0002198332,0.0002503339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008107813,0.00004655811,0.005644366,0.00003188776,0.00009873434,0.000002598962,0.0001127548,0.00007171479,0.9846128,0.00001051375,0.0002222035,0.008335148],"study_design_scores_gemma":[0.002046599,0.002285452,0.114605,0.0001508533,0.000103977,0.00003016338,0.00004173803,0.00151091,0.8736601,0.0003111114,0.005057133,0.0001969239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870492,0.0004748556,0.001253384,0.01085977,0.00009823182,0.0002307249,0.00001024346,0.00001016726,0.00001338473],"genre_scores_gemma":[0.9963293,0.0001997602,0.002142107,0.0007091921,0.0005401854,0.000004090552,0.00002587797,0.00001666884,0.00003282609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1109526,"threshold_uncertainty_score":0.6252294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06269572043454023,"score_gpt":0.3379813092249564,"score_spread":0.2752855887904162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}