{"id":"W3007602001","doi":"10.1093/jcag/gwz047.207","title":"A208 HLA-DQA1*05 GENOTYPE PREDICTS ANTI-DRUG ANTIBODY FORMATION AND LOSS OF RESPONSE DURING INFLIXIMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE","year":2020,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Infliximab; Medicine; Inflammatory bowel disease; Internal medicine; Discontinuation; Adverse effect; Crohn's disease; Gastroenterology; Immunology; Cohort; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004474285,0.0002695935,0.0002450513,0.0004125674,0.0005068299,0.0006139369,0.0004429291,0.0004015809,0.002576985],"category_scores_gemma":[0.001644902,0.0001532852,0.0003879705,0.0007675063,0.0002691507,0.0002039848,0.0002340825,0.0005538371,0.0002243916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009328306,"about_ca_system_score_gemma":0.001054877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.09990477,"about_ca_topic_score_gemma":0.07992894,"domain_scores_codex":[0.9995611,0.0000690445,0.00003469577,0.00009705286,0.0001188473,0.000119263],"domain_scores_gemma":[0.998188,0.0001963762,0.0008607999,0.00008312823,0.000201957,0.0004697464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001631207,0.00002303796,0.9985844,0.000005656949,0.00002622326,0.00004935338,0.00001993838,0.00002737345,0.0003126914,0.000007789351,0.00007112643,0.0007094694],"study_design_scores_gemma":[0.000006394674,0.00005687376,0.9994659,0.000004125626,0.00001968382,0.0001651509,0.0000343925,0.0001079035,0.00004807898,0.000006758026,0.00008315864,0.000001622217],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991015,0.0002423461,0.00003935432,0.00004279716,0.000006293526,0.000005154823,0.000192069,0.000002303287,0.0003681638],"genre_scores_gemma":[0.9996496,0.00004262991,0.00003676954,0.0000157602,0.000005113567,0.000001586448,0.0001212131,9.500237e-7,0.0001263178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09990477,"threshold_uncertainty_score":0.1986465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005060080255437948,"score_gpt":0.2049214798823914,"score_spread":0.1998613996269535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}