{"id":"W3007604345","doi":"10.6084/m9.figshare.c.3615608","title":"Widespread recovery of methylation at gametic imprints in hypomethylated mouse stem cells following rescue with DNMT3A2","year":2016,"lang":"en","type":"article","venue":"Ulster University Research Portal (Ulster University)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Medical Research Council; Cereal Partners Worldwide; Ulster University","keywords":"Reprogramming; Biology; DNA methylation; Epigenetics; Methylation; Genomic imprinting; Methyltransferase; Genetics; Bisulfite sequencing; Embryonic stem cell; Stem cell; DNMT1; Molecular biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008018428,0.0002247655,0.0002960184,0.0009914316,0.0001530463,0.00001994102,0.0004769839,0.0002839938,0.00007183688],"category_scores_gemma":[0.00004961669,0.0002075727,0.0001765522,0.000883245,0.0002530219,0.00007920233,0.0005632814,0.0001990408,0.00002125545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002364893,"about_ca_system_score_gemma":0.0001890638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002627605,"about_ca_topic_score_gemma":0.001385143,"domain_scores_codex":[0.9974141,0.0006170705,0.0002454631,0.0006802471,0.0005077454,0.0005353945],"domain_scores_gemma":[0.9985312,0.0001734342,0.0001461026,0.0006129942,0.0003253977,0.0002108537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001129886,0.0001005556,0.02617255,0.00003126256,0.0001366156,0.0002271082,0.0001708614,0.0001284737,0.9691858,0.00003998234,0.00005932097,0.002617601],"study_design_scores_gemma":[0.002858127,0.0008500799,0.004619232,0.0001312092,0.00004745646,0.000002525733,0.000949321,0.00002110071,0.9818764,0.00003429783,0.008257529,0.0003527356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932271,0.00007836537,0.001766468,0.00005893604,0.00007330006,0.000412153,0.00006728322,0.00001621909,0.00430017],"genre_scores_gemma":[0.9635308,0.0003382659,0.0002861745,0.000006347001,0.00002005716,3.875586e-7,0.00003856259,0.000028364,0.03575102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03145085,"threshold_uncertainty_score":0.846457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02480441490962552,"score_gpt":0.2509152788500949,"score_spread":0.2261108639404694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}