{"id":"W3007626997","doi":"10.1016/j.cgh.2020.02.035","title":"Effectiveness of Ustekinumab Dose Escalation in Patients With Crohn’s Disease","year":2020,"lang":"en","type":"article","venue":"Clinical Gastroenterology and Hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Janssen Biotech; National Institute of Diabetes and Digestive and Kidney Diseases; Takeda Canada; AbbVie; Merck; Pfizer","keywords":"Medicine; Ustekinumab; Calprotectin; Gastroenterology; Internal medicine; Crohn's disease; Confidence interval; Inflammatory bowel disease; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002306762,0.0001302582,0.0003003727,0.00002979396,0.00002118649,0.00000267116,0.0001011659,0.0001593561,0.00001060777],"category_scores_gemma":[0.0002062176,0.000115288,0.00006544627,0.00003251291,0.0003863207,0.000005252467,0.0001084372,0.0001409105,0.00000312416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005346647,"about_ca_system_score_gemma":0.00005696293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001983663,"about_ca_topic_score_gemma":0.0000278884,"domain_scores_codex":[0.9983304,0.0006348963,0.0003719716,0.000399821,0.00005477115,0.000208167],"domain_scores_gemma":[0.9993671,0.00005830109,0.0001246445,0.0001762131,0.00006759762,0.0002061964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03905451,0.0002623936,0.9601114,0.0001042045,0.00004724301,0.0000859733,0.000008324373,0.00002985445,0.00006626882,0.00005899437,0.00003033325,0.0001404736],"study_design_scores_gemma":[0.005829716,0.001457255,0.992363,0.00001689122,0.00003761275,0.000001390636,0.000003659263,0.0001312663,0.00001950785,0.00003726865,0.00003304108,0.00006933541],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990941,0.00002753293,0.0003318904,0.0001449271,0.00007047488,0.0002860946,0.00002240482,0.000006521646,0.00001609191],"genre_scores_gemma":[0.9989856,0.00001462633,0.00008205284,0.0007518162,0.00003530774,0.00002021323,0.00009681989,0.0000119687,0.000001592011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0332248,"threshold_uncertainty_score":0.4701307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0102550770692289,"score_gpt":0.260792833013081,"score_spread":0.2505377559438521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}