{"id":"W3007691816","doi":"10.3389/fimmu.2020.00276","title":"T-Cell Immunotherapies Targeting Histocompatibility and Tumor Antigens in Hematological Malignancies","year":2020,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Fonds de Recherche du Québec - Santé","keywords":"Minor histocompatibility antigen; Antigen; Immunology; Immunotherapy; Major histocompatibility complex; Biology; Chimeric antigen receptor; Histocompatibility; Cancer immunotherapy; Cancer research; Human leukocyte antigen; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007410858,0.0005744817,0.004172955,0.0007041104,0.00006408168,0.00002485997,0.000399967,0.0005924969,0.0004437864],"category_scores_gemma":[0.0003234577,0.0004837631,0.0003597388,0.0006761821,0.0007955214,0.00005433253,0.0002898213,0.001798083,0.00002585512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007138481,"about_ca_system_score_gemma":0.0005074773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000119752,"about_ca_topic_score_gemma":0.00001002586,"domain_scores_codex":[0.9960667,0.000786723,0.0012326,0.0009146723,0.0002284108,0.0007708485],"domain_scores_gemma":[0.9986932,0.000269095,0.0003135402,0.0005813939,0.0000521716,0.00009054186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008769066,0.0006215848,0.0168043,0.02098968,0.0005913912,0.002269033,0.001631123,2.869804e-7,0.001433415,0.00008082181,0.00491843,0.949783],"study_design_scores_gemma":[0.001525139,0.0003485722,0.0006243575,0.003084771,0.00009189258,0.0003114925,0.000517341,0.00001875772,0.00005260655,0.0001541314,0.9928644,0.0004065128],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003908373,0.9924587,0.00007354456,0.0001490888,0.0005730179,0.002214413,0.00001630809,0.0000662043,0.0005403711],"genre_scores_gemma":[0.0003140179,0.9943904,0.004148146,0.0000785619,0.00005869862,0.0002674825,0.00007084489,0.00008262318,0.0005892725],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.987946,"threshold_uncertainty_score":0.9997614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03428676460040395,"score_gpt":0.3136169474172623,"score_spread":0.2793301828168584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}