{"id":"W3007701756","doi":"10.1038/s42003-020-0810-y","title":"Binding of the periplakin linker requires vimentin acidic residues D176 and E187","year":2020,"lang":"en","type":"article","venue":"Communications Biology","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Biotechnology and Biological Sciences Research Council; Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; Alberta Innovates Bio Solutions; Research Councils UK; Wellcome; University of Birmingham; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Genome Canada; Wellcome Trust","keywords":"Linker; Vimentin; Intermediate filament; Desmoplakin; Cell biology; Biophysics; Intermediate Filament Protein; Chemistry; Cytoskeleton; Plasma protein binding; Biochemistry; Biology; Cell; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000432048,0.0001566489,0.00006890269,0.00005247353,0.0001063431,0.0001384187,0.00009223827,0.0001777245,0.001202906],"category_scores_gemma":[0.00009561465,0.00006692023,0.0001240739,0.00005206525,0.0001363207,0.0001254353,0.0001566936,0.0001993163,0.0004030035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000156631,"about_ca_system_score_gemma":0.0001064117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004047534,"about_ca_topic_score_gemma":0.0005241915,"domain_scores_codex":[0.9999555,0.000007751371,0.000002529803,0.00001085428,0.00001172616,0.00001165161],"domain_scores_gemma":[0.9999412,0.00001282764,0.00001983645,0.000005383857,0.000004579564,0.0000162923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006117664,0.000005053382,0.0007880797,0.00001196869,0.000002692951,0.0001336099,0.00001306618,0.00009057875,0.9981906,0.000096133,0.00001464134,0.0005923461],"study_design_scores_gemma":[0.00001491438,0.000168191,0.03342338,0.000007125841,0.0000109387,0.001294102,0.0001157804,0.001791612,0.9604818,0.0001727094,0.002512611,0.000006855352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979683,0.00009360338,0.00137751,0.00002124146,0.000002611851,0.000002742938,0.0000546318,0.00001149462,0.0004678455],"genre_scores_gemma":[0.9987304,0.00004272243,0.0005558352,0.00001988118,8.961929e-7,0.0000022147,0.0001222725,0.000003789586,0.0005219114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001202906,"threshold_uncertainty_score":0.004024148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05378312266800794,"score_gpt":0.3301155074480639,"score_spread":0.276332384780056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}