{"id":"W3007701756","doi":"10.1038/s42003-020-0810-y","title":"Binding of the periplakin linker requires vimentin acidic residues D176 and E187","year":2020,"lang":"en","type":"article","venue":"Communications Biology","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Biotechnology and Biological Sciences Research Council; Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; Alberta Innovates Bio Solutions; Research Councils UK; Wellcome; University of Birmingham; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Genome Canada; Wellcome Trust","keywords":"Linker; Vimentin; Intermediate filament; Desmoplakin; Cell biology; Biophysics; Intermediate Filament Protein; Chemistry; Cytoskeleton; Plasma protein binding; Biochemistry; Biology; Cell; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002127853,0.00008738605,0.0001228974,0.00002535422,0.0001879014,0.000008219316,0.0008748989,0.0001737333,0.00002355913],"category_scores_gemma":[0.000285012,0.00006354538,0.000058996,0.000127212,0.00119265,0.000002002392,0.001311242,0.0001616806,0.000008607681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003894018,"about_ca_system_score_gemma":0.00005305982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001545567,"about_ca_topic_score_gemma":0.000034599,"domain_scores_codex":[0.9990301,0.0003794651,0.0001889058,0.0002076359,0.00003749047,0.0001563747],"domain_scores_gemma":[0.998821,0.00005383451,0.00008561844,0.0009343128,0.00005672206,0.00004856796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002798082,0.0000224559,0.05602407,0.000008440948,0.00004408183,1.737483e-7,0.0001126042,2.558168e-7,0.9397702,0.00203231,0.0005719958,0.001385452],"study_design_scores_gemma":[0.000699378,0.0004776328,0.01274982,0.00002720055,0.00003701404,0.00003887202,0.0006462136,0.0001370441,0.7975881,0.0004357204,0.1869177,0.0002452536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980867,0.009319415,0.00009512209,0.007416608,0.00004304967,0.0001752359,0.00002817481,0.000009692797,0.002045681],"genre_scores_gemma":[0.9961094,0.002515152,0.0006345593,0.0003104013,0.00004918808,0.00002116949,0.0001440942,0.000008989106,0.0002071005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1863457,"threshold_uncertainty_score":0.4394369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05378312266800794,"score_gpt":0.3301155074480639,"score_spread":0.276332384780056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}