{"id":"W3007731701","doi":"10.1093/jcag/gwz047.220","title":"A221 CROHN’S DISEASE POLYGENIC RISK SCORE IS ASSOCIATED WITH FECAL CALPROTECTIN CONCENTRATION IN ASYMPTOMATIC FIRST-DEGREE RELATIVES OF CROHN’S DISEASE PATIENTS","year":2020,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto","funders":"","keywords":"Calprotectin; Single-nucleotide polymorphism; Crohn's disease; Genome-wide association study; Medicine; Minor allele frequency; Imputation (statistics); Internal medicine; First-degree relatives; Disease; Inflammatory bowel disease; Family history; Biology; Genotype; Genetics; Missing data","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003045213,0.0004389796,0.0004610858,0.0007436993,0.000528399,0.0004380694,0.0002129623,0.0004029449,0.0038111],"category_scores_gemma":[0.001358552,0.0002003599,0.0005685965,0.0007640728,0.0001727515,0.0001457462,0.0002638517,0.0004140162,0.0003680947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001238864,"about_ca_system_score_gemma":0.00009729801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003289312,"about_ca_topic_score_gemma":0.002429855,"domain_scores_codex":[0.9997144,0.00007910291,0.00003411961,0.0001046208,0.00003480756,0.00003292777],"domain_scores_gemma":[0.9991825,0.0001998133,0.0003313399,0.00007675359,0.00005928592,0.0001502688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008394093,0.00006199923,0.9901708,0.00003060527,0.0003021879,0.001044151,0.0001333455,0.0001168085,0.003629386,0.00005090355,0.0004035924,0.003216851],"study_design_scores_gemma":[0.0000144373,0.00008664098,0.9977778,0.00000848377,0.000129256,0.001042992,0.00005398018,0.0004812917,0.0001765131,0.00004462784,0.0001789793,0.000005035151],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990932,0.0002292235,0.0001637538,0.00003664475,0.000008131858,0.000002749591,0.0002162864,0.000009357453,0.0002407264],"genre_scores_gemma":[0.9995033,0.00003765269,0.0001199804,0.00001147377,0.000007954166,0.000002536739,0.0001598055,0.000002996886,0.0001542917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0038111,"threshold_uncertainty_score":0.01274937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007477684017351148,"score_gpt":0.1948955109863001,"score_spread":0.1874178269689489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}