{"id":"W3007745241","doi":"10.1101/2020.02.21.958801","title":"Prognostic significance of <i>SOCS1</i> and <i>SOCS3</i> tumor suppressors in hepatocellular carcinoma and its correlation to key oncogenic signaling pathways","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Université de Sherbrooke","keywords":"SOCS3; Suppressor of cytokine signaling 1; Hepatocellular carcinoma; Cancer research; Biology; SOCS2; Suppressor of cytokine signalling; Signal transduction; Gene; Suppressor; Cell biology; STAT3; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004350225,0.0005575347,0.001007458,0.0003783369,0.00009757284,0.00008290394,0.0002015415,0.0003160715,0.00002451663],"category_scores_gemma":[0.0009569848,0.0006147354,0.0001477174,0.0005930281,0.00008750147,0.0001336421,0.00035848,0.0009789144,0.00001298564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001871819,"about_ca_system_score_gemma":0.0006583368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001328497,"about_ca_topic_score_gemma":0.00000343039,"domain_scores_codex":[0.9969189,0.0001371759,0.0009283892,0.001125002,0.0004286108,0.0004619517],"domain_scores_gemma":[0.9976997,0.0002691491,0.0005063306,0.0005320313,0.000487156,0.0005056713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001670107,0.0001427212,0.1397823,0.001280758,0.00007215304,0.0002022102,0.0001380037,0.000165685,0.8578745,0.000132968,0.00004022564,0.000001508155],"study_design_scores_gemma":[0.001024823,0.0003653029,0.08963002,0.001856601,0.0003064063,4.46365e-7,0.00002090417,0.00958153,0.8962041,0.000003434266,0.0004467851,0.0005597121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935431,0.00222064,0.0007760737,0.0003547634,0.000360604,0.002217525,0.0003777466,0.0001413424,0.000008150287],"genre_scores_gemma":[0.9972754,0.0001188281,0.001611956,0.0003233609,0.0002427353,0.0002958016,0.000002338511,0.0001282239,0.000001371353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0501523,"threshold_uncertainty_score":0.9996304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02529941353161511,"score_gpt":0.2266650029376238,"score_spread":0.2013655894060087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}