{"id":"W3007762014","doi":"10.14309/ajg.0000000000000557","title":"Goals of Treatment for Improved Survival in Primary Biliary Cholangitis: Treatment Target Should Be Bilirubin Within the Normal Range and Normalization of Alkaline Phosphatase","year":2020,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":171,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Alberta; Toronto General Hospital; University Health Network","funders":"Dr. Falk Pharma; University of Thessaly; Erasmus Universitair Medisch Centrum Rotterdam; Universitat de Barcelona; Cilag; Astellas Pharma; Universiteit Gent; University of Alberta; Falk Foundation; National Institute for Health and Care Research; Università degli Studi di Padova; Friedrich-Schiller-Universität Jena; Intercept Pharmaceuticals; Gilead Sciences; Novartis Pharma; Norgine; Università degli Studi di Milano; University of Texas Southwestern Medical Center; Universitair Ziekenhuis Gent; Humanitas University; Arizona State University","keywords":"Bilirubin; Ursodeoxycholic acid; Medicine; Internal medicine; Gastroenterology; Hazard ratio; Alkaline phosphatase; Cohort; Liver transplantation; Proportional hazards model; Confidence interval; Transplantation; Chemistry; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001224558,0.0002222652,0.0005724085,0.0003581316,0.0001622609,0.0005964712,0.0001968345,0.0004432928,0.0007605536],"category_scores_gemma":[0.002427495,0.00007092817,0.0002340019,0.000435538,0.0002676338,0.000307023,0.0002583855,0.0003971486,0.0002293501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005319772,"about_ca_system_score_gemma":0.0009312433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003795832,"about_ca_topic_score_gemma":0.0005853533,"domain_scores_codex":[0.9995096,0.0001985422,0.00006002237,0.00005207652,0.0001304953,0.00004931565],"domain_scores_gemma":[0.9988299,0.0002797582,0.0005947844,0.00003446797,0.0001386143,0.0001224857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00224033,0.0003720665,0.8907471,0.0007996198,0.0002852546,0.0003789985,0.0001222791,0.001939778,0.003810002,0.0007163768,0.005835784,0.09275243],"study_design_scores_gemma":[0.0003297659,0.001999579,0.978513,0.0005379316,0.0003563091,0.002625359,0.0002116648,0.002763125,0.003344689,0.002915444,0.006370849,0.00003228202],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9526921,0.0297,0.004471675,0.006723505,0.0002124868,0.0001041368,0.0007792437,0.00009130844,0.005225564],"genre_scores_gemma":[0.9928116,0.003072262,0.002420467,0.0006636545,0.0001897648,0.00005807759,0.0005148121,0.00001012701,0.0002593533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001224558,"threshold_uncertainty_score":0.006476164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02863864115548184,"score_gpt":0.2754700004693986,"score_spread":0.2468313593139167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}