{"id":"W3007781983","doi":"10.1093/jcag/gwz047.199","title":"A200 HUMANIZED CELIAC-PRONE EPITHELIUM IN VITRO EXPRESS MHC-II AND CO-STIMULATORY MOLECULES NECESSARY FOR GLUTEN PEPTIDE PRESENTATION","year":2020,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Celiac Disease Research and Management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"","keywords":"Gliadin; MHC class I; Antigen presentation; CD80; Major histocompatibility complex; MHC class II; Immunology; Gluten; Biology; Immune system; In vitro; CD40; T cell; Cytotoxic T cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002697524,0.0003590723,0.0002534819,0.0001733016,0.0001531671,0.0004203604,0.0001502748,0.0003460975,0.003806396],"category_scores_gemma":[0.000124761,0.0001622853,0.0003379005,0.0001985642,0.000118375,0.0002140373,0.0002157286,0.0006685004,0.001135842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001531775,"about_ca_system_score_gemma":0.0001453467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008803617,"about_ca_topic_score_gemma":0.0008047316,"domain_scores_codex":[0.9997614,0.00004779869,0.00002764361,0.00006230908,0.00004687368,0.0000540482],"domain_scores_gemma":[0.9998403,0.00006023448,0.00001472518,0.00003347844,0.00001875071,0.00003245702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001176483,0.00004286553,0.0001265425,0.00003907971,0.000003878175,0.00005228536,0.00002200946,0.00002803084,0.9991146,0.00002817548,0.00003910126,0.0003856461],"study_design_scores_gemma":[0.000038074,0.00113813,0.00737529,0.00002740396,0.00003660061,0.0004696401,0.0001517114,0.0008333303,0.984409,0.00005862157,0.005454718,0.000007509982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876078,0.002679643,0.003581828,0.0001262175,0.000109331,0.00008210738,0.001046287,0.00009668333,0.00467009],"genre_scores_gemma":[0.9853129,0.00119873,0.003831256,0.0001287484,0.00002312978,0.0000504216,0.003173973,0.00002876237,0.006252025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003806396,"threshold_uncertainty_score":0.01273364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01526925835428789,"score_gpt":0.2713553572502367,"score_spread":0.2560860988959489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}