{"id":"W3007796728","doi":"10.3390/pharmaceutics12020183","title":"Non-Viral in Vitro Gene Delivery: It is Now Time to Set the Bar!","year":2020,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Gene delivery; Context (archaeology); Computer science; Set (abstract data type); Underpinning; Computational biology; Vector (molecular biology); Transfection; Biology; Risk analysis (engineering); Data science; Gene; Medicine; Genetics; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002008697,0.0004766988,0.0007542616,0.00007525746,0.00006284044,0.00005685475,0.0008813416,0.0003105933,0.0002434964],"category_scores_gemma":[0.00002336731,0.0003656737,0.0004120079,0.0002190847,0.00005035322,0.000003963902,0.0005318664,0.0004569115,0.003781167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005418565,"about_ca_system_score_gemma":0.0002946141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007249143,"about_ca_topic_score_gemma":0.000004086803,"domain_scores_codex":[0.9981536,0.000118664,0.0004838196,0.0006180251,0.0001902327,0.0004357049],"domain_scores_gemma":[0.9990437,0.00002558331,0.0001422807,0.0005270056,0.00007231139,0.0001891441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001350985,0.00005804463,0.000003052827,0.001043377,0.0004557626,0.0000688705,0.0001627193,0.0000122275,0.05038917,2.495354e-7,0.2781786,0.6694928],"study_design_scores_gemma":[0.0002008425,0.00009229031,4.274403e-7,0.0002899783,0.0003236932,0.00002876904,0.000009821179,0.0001847712,0.03670446,0.000001393418,0.9617527,0.0004108251],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005728421,0.9954883,0.00003136609,0.001263279,0.0002600446,0.0008219801,0.0006346498,0.00001187706,0.0009156548],"genre_scores_gemma":[0.0003566676,0.985428,0.0001077007,0.009912574,0.000667515,0.00009415024,0.0006367759,0.000069409,0.002727201],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6835741,"threshold_uncertainty_score":0.9998795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05985772415039132,"score_gpt":0.3666277781989967,"score_spread":0.3067700540486054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}