{"id":"W3007813417","doi":"10.1101/2020.03.02.972950","title":"Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Horizon 2020 Framework Programme; Cancéropôle Grand Ouest; Institut National Du Cancer; Vetenskapsrådet; Fondation ARC pour la Recherche sur le Cancer; Fondation pour la Recherche Médicale; European Commission","keywords":"XBP1; Unfolded protein response; RNA splicing; Endoplasmic reticulum; Cell biology; RNase P; Phosphorylation; Tyrosine kinase; Signal transduction; Biology; Chemistry; Biochemistry; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001199493,0.0001873422,0.0001769181,0.00010169,0.0001018104,0.0002274227,0.0001659891,0.0001674811,0.001948391],"category_scores_gemma":[0.00009743477,0.0000799749,0.0002050724,0.00009207051,0.0001473119,0.000177934,0.000156172,0.0005426785,0.0003528002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002781659,"about_ca_system_score_gemma":0.0001516319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003709065,"about_ca_topic_score_gemma":0.0003280177,"domain_scores_codex":[0.9999154,0.00001008529,0.00000585692,0.00002293101,0.00001419055,0.00003154822],"domain_scores_gemma":[0.9999391,0.000006156165,0.00002138561,0.000005607905,0.00000732506,0.0000205968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001668917,0.00001285522,0.0002093988,0.00002122255,0.00000292381,0.00002767647,0.000004854507,0.00004180198,0.9990434,0.00005346784,0.00002205229,0.0003934104],"study_design_scores_gemma":[0.0000410179,0.0001631356,0.01257687,0.000009575329,0.00001571784,0.0002520307,0.00003722451,0.001781344,0.9837002,0.0001083806,0.001307647,0.000006761841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962758,0.001399753,0.001167099,0.00009338725,0.00002448401,0.00001184102,0.0002517842,0.0000238381,0.0007520075],"genre_scores_gemma":[0.9981851,0.0003729872,0.0004363056,0.00003305584,0.00000582218,0.00001137123,0.0002142776,0.000006476815,0.0007346956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001948391,"threshold_uncertainty_score":0.006518006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0131200634309491,"score_gpt":0.2247182922290289,"score_spread":0.2115982287980799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}