{"id":"W3007831122","doi":"10.1016/j.neurobiolaging.2020.02.017","title":"Leucine-rich repeat kinase-2 (LRRK2) modulates microglial phenotype and dopaminergic neurodegeneration","year":2020,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Canadian Institutes of Health Research","keywords":"LRRK2; Microglia; Neurodegeneration; Cell biology; Biology; Substantia nigra; Knockout mouse; Inflammation; Dopaminergic; Immunology; Neuroscience; Medicine; Internal medicine; Dopamine; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003757257,0.0001554594,0.0002845429,0.00005869148,0.00005909058,0.000007344955,0.00004750982,0.00005860929,0.00002415916],"category_scores_gemma":[0.00003689478,0.0001333275,0.00005078716,0.00009883409,0.00007478025,0.00004390669,0.00005363262,0.0001030821,0.000009239666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008984391,"about_ca_system_score_gemma":0.00002501457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001476616,"about_ca_topic_score_gemma":0.000001381136,"domain_scores_codex":[0.9991164,0.0000560843,0.0001964045,0.0003935669,0.00006113822,0.0001764276],"domain_scores_gemma":[0.999567,0.00002943549,0.00008299547,0.000151094,0.0000471319,0.0001223679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000199685,0.0001039707,0.04317543,0.0000953872,0.00007238016,0.0001462227,0.0001649447,0.00009135694,0.9535682,0.0001490491,0.0001695257,0.002063837],"study_design_scores_gemma":[0.004243117,0.00179682,0.1381008,0.00005321204,0.0004492121,0.0001238631,0.00003917513,0.003050989,0.8501372,0.0001207016,0.00161559,0.000269292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967448,0.0006381336,0.00007677721,0.001991448,0.0001487204,0.0001686412,0.00001723224,0.00006008607,0.0001542131],"genre_scores_gemma":[0.9974001,0.0001133398,0.0006032659,0.001568642,0.0001533684,0.000003683628,0.00005965319,0.00002041072,0.00007751765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.103431,"threshold_uncertainty_score":0.5436935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01899982452894735,"score_gpt":0.2401723585536155,"score_spread":0.2211725340246682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}