{"id":"W3007846944","doi":"10.1200/jco.2020.38.6_suppl.729","title":"Evaluation of RNA-sequencing (RNA-seq) signatures with pembrolizumab (pembro) in patients (pts) with renal cell carcinoma (RCC) from KEYNOTE-427 cohort A.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Cohort; Oncology; Angiogenesis; Stromal cell; Proportional hazards model; RNA-Seq; Internal medicine; Renal cell carcinoma; Cancer research; Gene expression; Transcriptome; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"observational","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"observational","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006860227,0.0002013583,0.0003448179,0.0002439745,0.0002183301,0.0005051192,0.0002683858,0.0003321708,0.00174588],"category_scores_gemma":[0.001136036,0.0001538784,0.0004461805,0.0003926209,0.000140299,0.0002166981,0.0003043187,0.0003184446,0.0003472902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003575568,"about_ca_system_score_gemma":0.0004985856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001426907,"about_ca_topic_score_gemma":0.00324569,"domain_scores_codex":[0.9996434,0.00007014311,0.00002226147,0.0001644288,0.00006408012,0.00003562622],"domain_scores_gemma":[0.999518,0.0001045107,0.0001366462,0.00007043118,0.00007494786,0.00009539248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01927314,0.0005176091,0.9121267,0.0003664411,0.001237432,0.0002547352,0.0002054239,0.001319878,0.03431186,0.0001586636,0.004480334,0.02574783],"study_design_scores_gemma":[0.0007731477,0.003197904,0.9816984,0.00004019855,0.0006474792,0.0006229737,0.0002100993,0.002290956,0.0049256,0.0001559584,0.00541808,0.00001939379],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912062,0.0003918819,0.0003606428,0.00005957343,0.00001213473,0.00007557256,0.00726627,0.0000177615,0.000609787],"genre_scores_gemma":[0.9780989,0.0001629643,0.0006116234,0.0001550146,0.00002215426,0.0001581518,0.02010326,0.00001396279,0.0006739484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00174588,"threshold_uncertainty_score":0.00584054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1142373535988604,"score_gpt":0.3762629841007573,"score_spread":0.2620256305018969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}