{"id":"W3007870553","doi":"10.1200/jco.2020.38.6_suppl.120","title":"Results of a phase I/II prospective dose-escalation trial evaluating safety and efficacy of combination 177LuPSMA-617 and NOX66 in men with mCRPC post androgen signalling inhibition and two lines of taxane chemotherapy (LuPIN trial).","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Taxane; Cabazitaxel; Prostate cancer; Docetaxel; Internal medicine; Oncology; Urology; Androgen deprivation therapy; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003140748,0.001515376,0.001736553,0.0004597023,0.0004762725,0.0008330533,0.0006855253,0.001512221,0.004949195],"category_scores_gemma":[0.001391336,0.0006633233,0.001224117,0.0003741068,0.001004892,0.000972391,0.000421285,0.00253743,0.0009888385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006600586,"about_ca_system_score_gemma":0.0009960562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004789157,"about_ca_topic_score_gemma":0.001079915,"domain_scores_codex":[0.9991261,0.0005207495,0.00004211501,0.000115942,0.0000651462,0.0001298759],"domain_scores_gemma":[0.9988666,0.0002180393,0.000233493,0.0001258055,0.00007027193,0.0004858284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8561946,0.06514303,0.005922589,0.0004581543,0.001031918,0.0002795886,0.0003511518,0.001760196,0.02892634,0.0001843113,0.002031035,0.03771721],"study_design_scores_gemma":[0.5379036,0.4450127,0.01117157,0.00002768214,0.0005003456,0.0002381956,0.00005019792,0.0006647022,0.002677888,0.0002807119,0.001448828,0.00002357014],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902501,0.001049876,0.0007224825,0.0003462402,0.00007187347,0.004675816,0.001209253,0.00007067918,0.001603787],"genre_scores_gemma":[0.985502,0.0008924255,0.002402818,0.0008880469,0.0001160902,0.004625847,0.002851025,0.00004320602,0.002678551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004949195,"threshold_uncertainty_score":0.01661009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1391361220339376,"score_gpt":0.4996903683861957,"score_spread":0.3605542463522581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}