{"id":"W3007878751","doi":"10.1093/humrep/dez203","title":"Cost effectiveness of in vitro fertilisation and preimplantation genetic testing to prevent transmission of BRCA1/2 mutations","year":2020,"lang":"en","type":"article","venue":"Human Reproduction","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University of Waterloo; Sunnybrook Health Science Centre; Sinai Health System; Canadian Centre for Applied Research in Cancer Control; Health Sciences Centre","funders":"","keywords":"Genetic testing; Population; Cohort; Medicine; BRCA mutation; In vitro fertilisation; Cancer; Genetics; Biology; Breast cancer; Internal medicine; Pregnancy; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006991317,0.000760159,0.001530709,0.0007622412,0.0002599008,0.001269012,0.001563062,0.001415772,0.00642636],"category_scores_gemma":[0.02471023,0.0005071875,0.003229981,0.0007662662,0.0004486238,0.001490989,0.0008321928,0.00140058,0.0001633746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005793121,"about_ca_system_score_gemma":0.005714427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03248525,"about_ca_topic_score_gemma":0.01842607,"domain_scores_codex":[0.9971907,0.002005418,0.000105125,0.0002191537,0.0001952061,0.0002845083],"domain_scores_gemma":[0.9828053,0.01514851,0.0008783989,0.0002127107,0.000430514,0.0005245265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.01348227,0.001824073,0.04624093,0.001715377,0.003876304,0.0001519188,0.000160658,0.8593971,0.0006034918,0.005397831,0.002222671,0.06492738],"study_design_scores_gemma":[0.007373522,0.01274034,0.05512405,0.001039173,0.008431357,0.0003438111,0.000556233,0.9010438,0.001478921,0.008930858,0.002784513,0.0001534157],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9670777,0.003254574,0.01468919,0.004049706,0.0001760827,0.001043463,0.002518953,0.0001136987,0.007076684],"genre_scores_gemma":[0.9946876,0.0005599042,0.003304918,0.0003568113,0.00001514241,0.0001976015,0.0004498607,0.000007380277,0.0004206551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03248525,"threshold_uncertainty_score":0.0645923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04791207968564761,"score_gpt":0.317011617640271,"score_spread":0.2690995379546234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}