{"id":"W3007918331","doi":"10.1002/cpsc.106","title":"Modeling Epithelial Homeostasis and Reactive Epithelial Changes in Human and Murine Three‐Dimensional Esophageal Organoids","year":2020,"lang":"en","type":"article","venue":"Current Protocols in Stem Cell Biology","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Alcohol Abuse and Alcoholism; North American Society for Pediatric Gastroenterology, Hepatology and Nutrition; National Center for Advancing Translational Sciences; American Partnership for Eosinophilic Disorders; Children's Hospital of Philadelphia; National Cancer Institute; National Science Foundation","keywords":"Organoid; Ex vivo; Biology; Eosinophilic esophagitis; Epithelium; Homeostasis; Cell biology; Immunology; Pathology; In vivo; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003645849,0.000369836,0.0006609079,0.0002043026,0.0001676874,0.00001650419,0.0002186985,0.0004318165,0.00006243674],"category_scores_gemma":[0.00003477012,0.0003244663,0.00004482333,0.0002157699,0.0003403608,0.00009107101,0.0003758551,0.0007135538,0.00003921135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000514489,"about_ca_system_score_gemma":0.00008987248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009590959,"about_ca_topic_score_gemma":0.0002702445,"domain_scores_codex":[0.9976783,0.000391454,0.0005085483,0.0007926556,0.00004363013,0.0005853757],"domain_scores_gemma":[0.9994078,0.0001107202,0.0001442748,0.000200392,0.0000648211,0.00007197194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001052673,0.0003831306,0.01586434,0.0004609131,0.00004457746,0.0000278051,0.002470909,0.00004659655,0.9350588,0.0008197919,0.00003490443,0.04373552],"study_design_scores_gemma":[0.02594532,0.006028991,0.006152405,0.0007950342,0.00008506589,0.00009004712,0.0008664859,0.002509631,0.9126321,0.002536234,0.04038509,0.001973582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808813,0.002102618,0.0001037223,0.0001392251,0.0002784125,0.0152814,0.001065944,0.00005623547,0.00009110088],"genre_scores_gemma":[0.9908071,0.0001415038,0.00005295925,0.0001043985,0.0001562806,0.008517567,0.0001721105,0.00002813473,0.00001995979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04176194,"threshold_uncertainty_score":0.9999207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0504023174386464,"score_gpt":0.296082183271386,"score_spread":0.2456798658327396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}