{"id":"W3007921512","doi":"10.1074/jbc.ra119.011212","title":"Structural analyses of the Group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations","year":2020,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Microbial bioremediation and biosurfactants","field":"Environmental Science","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université Laval","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Cofactor; Bridging (networking); Flavin group; Monooxygenase; Chemistry; Stereochemistry; Flavoprotein; Flavin adenine dinucleotide; Group (periodic table); Biochemistry; Enzyme; Organic chemistry; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008150572,0.0002638585,0.0002213832,0.0002431895,0.0002121229,0.0002520853,0.0002261905,0.0003557217,0.0005119096],"category_scores_gemma":[0.0002252634,0.0001267271,0.0002407172,0.0002813712,0.0002803227,0.0004374453,0.0002478593,0.0007839933,0.0001497961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001922821,"about_ca_system_score_gemma":0.0001275796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006464216,"about_ca_topic_score_gemma":0.0006824131,"domain_scores_codex":[0.9999505,0.000003668478,0.000002776289,0.00001578929,0.00001545389,0.00001178791],"domain_scores_gemma":[0.9999003,0.00002111573,0.00002895699,0.000009974767,0.00001203005,0.00002750017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002418158,0.00009227001,0.00994807,0.0001590002,0.00003463876,0.001086985,0.0002453972,0.001684297,0.9714571,0.0009504656,0.0003977473,0.01370216],"study_design_scores_gemma":[0.00003179509,0.0004359576,0.1315914,0.00003819135,0.00008560206,0.005285316,0.0007083451,0.02766532,0.8117862,0.001123983,0.02115426,0.00009357617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936149,0.001326305,0.00364401,0.0001299284,0.00001454383,0.0000101297,0.0003596841,0.00007058292,0.0008297972],"genre_scores_gemma":[0.9936562,0.000807241,0.003796789,0.00006157183,0.000007223271,0.000005357476,0.001019652,0.00001101071,0.0006349493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006464216,"threshold_uncertainty_score":0.001712501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05324776153043634,"score_gpt":0.2720808174413609,"score_spread":0.2188330559109245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}