{"id":"W3007935659","doi":"10.1101/2020.02.25.964650","title":"Control of tissue development by cell cycle dependent transcriptional filtering","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canada First Research Excellence Fund; University of Toronto","keywords":"Multicellular organism; Cell cycle; Biology; Cell; Gene; Computational biology; Organism; Cell growth; Cell fate determination; Cell biology; Genome; Gene expression; Embryonic stem cell; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001518626,0.0001693179,0.0002699868,0.0002042119,0.0001608359,0.000587895,0.0002602534,0.0002114004,0.001510826],"category_scores_gemma":[0.00045796,0.0001790285,0.0001775556,0.0001555353,0.0003201581,0.0003134628,0.000237832,0.0002579853,0.000401196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004766553,"about_ca_system_score_gemma":0.0002669096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008942105,"about_ca_topic_score_gemma":0.0008914061,"domain_scores_codex":[0.9999156,0.000009026072,0.000003317597,0.00003484422,0.00002038239,0.0000167968],"domain_scores_gemma":[0.9997687,0.00009536382,0.00004763449,0.00002750499,0.00002865294,0.00003224066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004426329,0.00001292504,0.001038174,0.00002574435,0.000006653428,0.00002351456,0.00001780173,0.009454162,0.9798464,0.003975901,0.0002020515,0.005352451],"study_design_scores_gemma":[0.00004591779,0.00008279892,0.01283214,0.00001341774,0.00001816778,0.00008191291,0.00003353646,0.4056641,0.562726,0.01237728,0.006080384,0.00004434917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8488979,0.0008598198,0.143029,0.0003072064,0.00007555057,0.00002324108,0.0004606009,0.0007161271,0.005630327],"genre_scores_gemma":[0.9906814,0.000223955,0.006667641,0.00006265799,0.00001524687,0.00002083301,0.0001503899,0.00009705028,0.002080942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001510826,"threshold_uncertainty_score":0.005054235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01020674488152044,"score_gpt":0.1977288159579688,"score_spread":0.1875220710764483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}