{"id":"W3007940209","doi":"10.1371/journal.pgen.1008613","title":"Planarian EGF repeat-containing genes megf6 and hemicentin are required to restrict the stem cell compartment","year":2020,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Planarian Biology and Electrostimulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Ontario Institute for Cancer Research; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; University of Toronto; Ontario Institute for Cancer Research","keywords":"Biology; Planarian; Stem cell; Cell biology; Compartment (ship); Ectopic expression; Regeneration (biology); Extracellular matrix; Cellular differentiation; Induced pluripotent stem cell; Adult stem cell; Stem cell marker; Population; Genetics; Gene; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000544704,0.0004409813,0.0001603627,0.0002982225,0.0001300243,0.0002102871,0.0002701833,0.0003057786,0.001407526],"category_scores_gemma":[0.00008102032,0.0001597371,0.0001397584,0.0001239823,0.0003516811,0.0001943764,0.0004180837,0.0005305128,0.0003898221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002566707,"about_ca_system_score_gemma":0.0001596162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005398636,"about_ca_topic_score_gemma":0.001125711,"domain_scores_codex":[0.9999199,0.00000709475,0.000006038424,0.00001884327,0.0000344114,0.00001368172],"domain_scores_gemma":[0.9998912,0.00001427391,0.00004870868,0.000009985753,0.00001019365,0.00002551289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002138908,0.000001998924,0.0001030027,0.00001356366,0.000001391492,0.00004472584,0.000004319829,0.00004051192,0.998988,0.0001290827,0.00001276336,0.0006392031],"study_design_scores_gemma":[0.000009071419,0.0000324585,0.009061399,0.000004801497,0.000008600983,0.0004715,0.00003006095,0.001050696,0.983548,0.0001015984,0.005675737,0.000006167415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862108,0.0008917529,0.008665438,0.0001462169,0.00002542643,0.00002156874,0.0009410065,0.0003166537,0.002781301],"genre_scores_gemma":[0.9841869,0.000463858,0.005280608,0.00006020781,0.00000597086,0.0000323269,0.001014057,0.00009024199,0.008865664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001407526,"threshold_uncertainty_score":0.004708648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03114090781059589,"score_gpt":0.2280311390828668,"score_spread":0.196890231272271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}