{"id":"W3007940209","doi":"10.1371/journal.pgen.1008613","title":"Planarian EGF repeat-containing genes megf6 and hemicentin are required to restrict the stem cell compartment","year":2020,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Planarian Biology and Electrostimulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Ontario Institute for Cancer Research; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; University of Toronto; Ontario Institute for Cancer Research","keywords":"Biology; Planarian; Stem cell; Cell biology; Compartment (ship); Ectopic expression; Regeneration (biology); Extracellular matrix; Cellular differentiation; Induced pluripotent stem cell; Adult stem cell; Stem cell marker; Population; Genetics; Gene; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008983569,0.0001613219,0.0001572114,0.00001925634,0.0001613402,0.00003154945,0.0001869793,0.0001353074,0.00000407213],"category_scores_gemma":[0.00002475337,0.0001327433,0.00003563086,0.00008716506,0.00004154467,0.000002198654,0.0001280384,0.00009419391,0.00001339617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001080182,"about_ca_system_score_gemma":0.00003516047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002323691,"about_ca_topic_score_gemma":0.00002118032,"domain_scores_codex":[0.9989534,0.00009364912,0.0002092481,0.000380372,0.0000977329,0.0002655731],"domain_scores_gemma":[0.999428,0.00002665276,0.000100996,0.0002533896,0.00004343206,0.0001475207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003684894,0.00003980344,0.03671391,0.00002355202,0.00008894351,0.00001050788,0.0003172338,0.0009247231,0.9521258,0.00002030587,0.008510198,0.0008565174],"study_design_scores_gemma":[0.0006968658,0.0009418368,0.005704245,0.00001591234,0.00009328222,0.00001361416,0.0003071773,0.003604427,0.9238247,0.0000181005,0.06446572,0.0003141468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891675,0.002820759,0.0003692398,0.00693029,0.0000581861,0.0003216788,0.00004314863,0.00002039673,0.0002688297],"genre_scores_gemma":[0.994359,0.0002556072,0.0002179212,0.004612703,0.0002552631,0.00001664661,0.0001590079,0.00001783889,0.0001059779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05595552,"threshold_uncertainty_score":0.5413114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03114090781059589,"score_gpt":0.2280311390828668,"score_spread":0.196890231272271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}