{"id":"W3008016882","doi":"10.1007/s00262-020-02507-w","title":"miRNA-5119 regulates immune checkpoints in dendritic cells to enhance breast cancer immunotherapy","year":2020,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"National Natural Science Foundation of China","keywords":"Immune system; Immunotherapy; Cancer research; microRNA; Biology; Dendritic cell; Cancer immunotherapy; CD8; T cell; Breast cancer; Immunology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow","insufficient_payload"],"category_scores_codex":[0.0007165163,0.001446201,0.002170868,0.0007467978,0.0005333577,0.0001399204,0.00245525,0.001178492,0.008850888],"category_scores_gemma":[0.00007702625,0.001444235,0.0006924277,0.001892291,0.001054612,0.0006488867,0.0003272499,0.001906387,0.001664781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007372155,"about_ca_system_score_gemma":0.0007039363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003221707,"about_ca_topic_score_gemma":0.0001510845,"domain_scores_codex":[0.9921432,0.001186723,0.002173108,0.001808194,0.0002340812,0.002454694],"domain_scores_gemma":[0.9966762,0.0004252703,0.0006935886,0.001694561,0.0003717267,0.0001386365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01275165,0.0004386379,0.001470682,0.00005214928,0.001752026,0.00003402421,0.00563764,0.0001482807,0.8782607,0.00009653049,0.002142663,0.097215],"study_design_scores_gemma":[0.006978047,0.0007626308,0.04804412,0.0004568285,0.00005231525,0.0001476946,0.0006897157,0.00001232361,0.802704,0.00008251614,0.1385251,0.001544782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7245003,0.2529338,0.0002449145,0.01578934,0.003705139,0.001694834,0.0003136339,0.0006769451,0.0001411448],"genre_scores_gemma":[0.9240584,0.05821335,0.0002453142,0.01125547,0.000218509,0.001674266,0.00008237897,0.0005311883,0.003721092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1995582,"threshold_uncertainty_score":0.9998288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112787090319666,"score_gpt":0.2752890135284139,"score_spread":0.2641611426252172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}