{"id":"W3008046944","doi":"10.3390/jcm9030625","title":"A New Risk Variant for Multiple Sclerosis at 11q23.3 Locus Is Associated with Expansion of CXCR5+ Circulating Regulatory T Cells","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Medicine","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Agencia Estatal de Investigación; Instituto de Salud Carlos III; Generalitat de Catalunya; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Direcció General de Recerca, Generalitat de Catalunya; European Regional Development Fund; Red Española de Esclerosis Múltiple","keywords":"Linkage disequilibrium; Locus (genetics); Minor allele frequency; Genetics; Genome-wide association study; Genetic association; Medicine; Multiple sclerosis; Allele; Biology; Haplotype; Gene; Single-nucleotide polymorphism; Allele frequency; Genotype; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003497032,0.0006149067,0.0004275852,0.0006895869,0.0002942855,0.0002957058,0.0003186445,0.0005803987,0.002481105],"category_scores_gemma":[0.001042453,0.0001755111,0.0005110214,0.0007220336,0.0002681122,0.00008507202,0.0002065662,0.0003844209,0.0002029156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001883585,"about_ca_system_score_gemma":0.0001389274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001521013,"about_ca_topic_score_gemma":0.001520616,"domain_scores_codex":[0.999607,0.0001021374,0.00003947556,0.000155003,0.00005983595,0.00003664395],"domain_scores_gemma":[0.9993935,0.0001928905,0.0002719074,0.0000497705,0.00002604501,0.0000659427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004619316,0.0001892719,0.7638184,0.0002024563,0.0009938169,0.01192065,0.0004112409,0.001029181,0.1857922,0.0004987827,0.0006855428,0.02983922],"study_design_scores_gemma":[0.0001640424,0.000512719,0.9793023,0.0000238498,0.0003904215,0.01097741,0.00005573226,0.001340664,0.005964329,0.0002877492,0.0009588525,0.00002206246],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985538,0.0002980406,0.0006043575,0.00007122606,0.000009866015,0.000009032074,0.0002353411,0.00002526116,0.0001930898],"genre_scores_gemma":[0.9991116,0.00007985805,0.0004219514,0.00002849064,0.00001634633,0.000005709998,0.0001886502,0.000005435855,0.0001420075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002481105,"threshold_uncertainty_score":0.008300126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07220897696379637,"score_gpt":0.2970854198321549,"score_spread":0.2248764428683585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}