{"id":"W3008053955","doi":"10.1101/2020.02.25.962068","title":"Genetic Profiling of Protein Burden and Nuclear Export Overload","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Overproduction; Saccharomyces cerevisiae; Nuclear export signal; Mutant; Biology; Green fluorescent protein; Nuclear protein; Cell biology; Gene; Nuclear transport; Genetics; Cell nucleus; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001671912,0.0004019425,0.0002456122,0.000425621,0.000154835,0.0003455102,0.0001904642,0.0002817468,0.0007688719],"category_scores_gemma":[0.0001287213,0.0001828243,0.0002017328,0.0002899556,0.0003110639,0.0001680187,0.0004519458,0.0005583588,0.0002958713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002706239,"about_ca_system_score_gemma":0.0001463908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006017534,"about_ca_topic_score_gemma":0.0006731161,"domain_scores_codex":[0.9997694,0.00003101793,0.00001946608,0.00005905652,0.00007953482,0.00004158396],"domain_scores_gemma":[0.9996744,0.00007462998,0.0001173752,0.00003935451,0.0000313411,0.00006288976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002073521,0.000004579985,0.0001384463,0.000005768622,0.000001813394,0.00002796707,0.000005810507,0.00002895954,0.9995832,0.00002738896,0.000006880862,0.0001485642],"study_design_scores_gemma":[0.000002798499,0.00004636406,0.005594862,0.000002576217,0.00000892314,0.0001934637,0.00003164044,0.0006711411,0.9927309,0.00003576548,0.0006772096,0.000004296798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902562,0.0003653963,0.007255091,0.00006336484,0.00001785091,0.0000236429,0.001044768,0.0001277127,0.0008460486],"genre_scores_gemma":[0.9897781,0.0003531669,0.005976898,0.00004934866,0.000006788855,0.00002638832,0.001333772,0.0001079832,0.002367529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007688719,"threshold_uncertainty_score":0.002572119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01396991577209993,"score_gpt":0.2279319708009915,"score_spread":0.2139620550288915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}