{"id":"W3008055052","doi":"10.1200/jco.2020.38.6_suppl.715","title":"Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma (S/R RCC) to reveal potential determinants of poor prognosis and response to immune checkpoint inhibitors (ICI).","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"CDKN2A; Cancer research; Immune checkpoint; Medicine; BAP1; Immune system; Transcriptome; Tumor microenvironment; CD8; Downregulation and upregulation; Cancer; Immunotherapy; Oncology; Internal medicine; Biology; Melanoma; Gene expression; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003778932,0.0002202331,0.0003253062,0.0008834061,0.0002788042,0.0003856049,0.0003330933,0.000244274,0.002040635],"category_scores_gemma":[0.0003254095,0.0001332101,0.0004397886,0.0007518052,0.0001462921,0.000142161,0.0003812739,0.0002633322,0.0004102984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004240636,"about_ca_system_score_gemma":0.0004861476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003512154,"about_ca_topic_score_gemma":0.01186317,"domain_scores_codex":[0.9998091,0.00001455889,0.00001264081,0.00008452147,0.00004509987,0.00003419039],"domain_scores_gemma":[0.9997644,0.00003690843,0.00008018436,0.00003938065,0.00003848102,0.00004059858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001286522,0.0001974837,0.4095767,0.0006037583,0.0006561363,0.0007507046,0.0003711589,0.002577743,0.5349373,0.0007993231,0.004167391,0.04407581],"study_design_scores_gemma":[0.00008042955,0.0004532141,0.9461125,0.00004022868,0.0004092941,0.001990528,0.0002538218,0.00321426,0.03619415,0.0002649778,0.01097036,0.00001623257],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833835,0.001004025,0.001525911,0.0001206122,0.00001019345,0.00006458281,0.01208495,0.00008545264,0.001720908],"genre_scores_gemma":[0.9715667,0.0003727604,0.003405703,0.0001544169,0.00001101771,0.00007020665,0.02347019,0.00003836196,0.0009107104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003512154,"threshold_uncertainty_score":0.006983399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04529062756487279,"score_gpt":0.3560150539376791,"score_spread":0.3107244263728063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}