{"id":"W3008133387","doi":"10.2337/dbi19-0014","title":"Nutrient-Induced Metabolic Stress, Adaptation, Detoxification, and Toxicity in the Pancreatic β-Cell","year":2020,"lang":"en","type":"letter","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Institute of Nutrition, Metabolism and Diabetes; Canadian Institutes of Health Research","keywords":"Lipotoxicity; Nutrient; Detoxification (alternative medicine); Biology; Insulin; Nutrient sensing; Metabolism; Toxicity; Metabolic pathway; Endocrinology; Insulin resistance; Internal medicine; Biochemistry; Medicine; Ecology; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000501494,0.0004458542,0.0003509779,0.0006439181,0.0004894422,0.001208943,0.0003452399,0.0007897568,0.0008160508],"category_scores_gemma":[0.0002217756,0.0001409528,0.0003490485,0.0003723094,0.001628947,0.001261008,0.0007470855,0.001523101,0.0002029643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004891649,"about_ca_system_score_gemma":0.0003172549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002819212,"about_ca_topic_score_gemma":0.0005127347,"domain_scores_codex":[0.9998061,0.00006287754,0.000026611,0.00002584905,0.0000542228,0.00002442408],"domain_scores_gemma":[0.999828,0.00005371711,0.00005262892,0.00001149022,0.00002603758,0.00002814131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002077687,0.0005086406,0.01191976,0.004254742,0.0001760467,0.008962659,0.001561238,0.001243487,0.5748621,0.06498491,0.01645329,0.3129954],"study_design_scores_gemma":[0.00009368118,0.006870059,0.07070436,0.001134271,0.0002912174,0.03483895,0.003335849,0.002917974,0.3769598,0.08734161,0.4152549,0.0002572157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1710362,0.7856259,0.01015009,0.01721106,0.003842997,0.00005764734,0.00008320763,0.0001758571,0.01181698],"genre_scores_gemma":[0.4495161,0.513409,0.005486438,0.0113589,0.005022017,0.000102277,0.0001349151,0.00005906247,0.01491132],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001208943,"threshold_uncertainty_score":0.003549099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02495146802906851,"score_gpt":0.233616854084629,"score_spread":0.2086653860555605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}