{"id":"W3008133387","doi":"10.2337/dbi19-0014","title":"Nutrient-Induced Metabolic Stress, Adaptation, Detoxification, and Toxicity in the Pancreatic β-Cell","year":2020,"lang":"en","type":"letter","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Institute of Nutrition, Metabolism and Diabetes; Canadian Institutes of Health Research","keywords":"Lipotoxicity; Nutrient; Detoxification (alternative medicine); Biology; Insulin; Nutrient sensing; Metabolism; Toxicity; Metabolic pathway; Endocrinology; Insulin resistance; Internal medicine; Biochemistry; Medicine; Ecology; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002114916,0.0003685945,0.0007544522,0.0002002065,0.0001032245,0.00008848847,0.0001961152,0.0003472941,0.0000986973],"category_scores_gemma":[0.0006043006,0.0002628636,0.0001183295,0.0004888144,0.0001004825,0.0000884883,0.00003305901,0.0009881334,0.00008376184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000384008,"about_ca_system_score_gemma":0.0001534731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003749298,"about_ca_topic_score_gemma":0.000001639692,"domain_scores_codex":[0.9978473,0.0002691572,0.0004711895,0.000519787,0.0004740427,0.0004185883],"domain_scores_gemma":[0.9983454,0.0007047507,0.000215559,0.0005127002,0.0001147752,0.0001068389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003810577,0.0003427303,0.07318193,0.001889391,0.0003066164,0.0001157181,0.00279688,0.000001946931,0.02977741,0.0002398811,0.8896474,0.001662005],"study_design_scores_gemma":[0.005629725,0.0007192214,0.04731176,0.0009660175,0.002926131,0.00001134166,0.002291799,0.002665369,0.192375,0.002619948,0.7410601,0.001423545],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6743947,0.004228908,0.00001704277,0.3181109,0.0001624831,0.0009236588,0.00007596349,0.00008782441,0.001998531],"genre_scores_gemma":[0.5046275,0.0003271975,0.0002045671,0.4921962,0.001162928,0.0002518008,0.0008215803,0.00004781441,0.0003604717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1740853,"threshold_uncertainty_score":0.9999824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02495146802906851,"score_gpt":0.233616854084629,"score_spread":0.2086653860555605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}