{"id":"W3008140434","doi":"10.1126/scitranslmed.aax2625","title":"BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers","year":2020,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Cancer Institute; National Institutes of Health; Institut National Du Cancer; Direction Générale de l’offre de Soins; Institut National de la Santé et de la Recherche Médicale","keywords":"Triple-negative breast cancer; Topoisomerase; Breast cancer; Cancer research; Medicine; Triple negative; Topoisomerase inhibitor; Cancer; Oncology; Biology; Internal medicine; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004855367,0.0001145092,0.0001312521,0.0001006129,0.00008409784,0.00001347471,0.0001531769,0.00003673546,0.00003701212],"category_scores_gemma":[0.0001121139,0.00009917608,0.00001894595,0.0005635615,0.0004458461,0.00001242805,0.00002557059,0.00007463527,0.000001199218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003850311,"about_ca_system_score_gemma":0.0004960276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001968904,"about_ca_topic_score_gemma":0.0002193703,"domain_scores_codex":[0.9988165,0.00003778897,0.0001882201,0.0004004585,0.0003451748,0.0002118601],"domain_scores_gemma":[0.9994861,0.00002970744,0.00003501054,0.0001022845,0.00008327665,0.0002636261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001990691,0.00001236565,0.001346271,0.0000105051,0.000008764341,0.00000915711,0.001849553,0.0003222038,0.985745,0.0002653621,0.0001594272,0.008280657],"study_design_scores_gemma":[0.02360136,0.00665028,0.1613099,0.0006910231,0.0001045556,0.0003208795,0.004827679,0.006661631,0.7351231,0.00378746,0.05520804,0.001714105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9664283,0.0005807351,0.001079339,0.0311165,0.0002273401,0.0003299947,0.00007564677,0.000008188198,0.000153964],"genre_scores_gemma":[0.9966444,0.00008995632,0.0002278302,0.002687975,0.0002697062,0.0000203568,0.00001315909,0.000008212643,0.00003840015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2506219,"threshold_uncertainty_score":0.4044283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01314497392111554,"score_gpt":0.2773179611807338,"score_spread":0.2641729872596182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}