{"id":"W3008140779","doi":"10.33380/2305-2066-2020-9-1-99-108","title":"Development and Validation of Atazanavir and Ritonavir Determination in Human Plasma by HPLC-MS Method","year":2020,"lang":"en","type":"article","venue":"Drug development & registration","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Public Health Association","funders":"","keywords":"Atazanavir; Ritonavir; Pharmacokinetics; Chromatography; Human plasma; Protein precipitation; Therapeutic drug monitoring; Chemistry; Pharmacology; Human immunodeficiency virus (HIV); Medicine; Antiretroviral therapy; Viral load; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002222857,0.0012021,0.0007458332,0.001639741,0.000819109,0.0007067723,0.0009359457,0.001781378,0.001572172],"category_scores_gemma":[0.002819176,0.0005631077,0.0008219285,0.0007240287,0.0006687954,0.0005386894,0.0005992445,0.001004754,0.001522005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005228883,"about_ca_system_score_gemma":0.002118807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008880393,"about_ca_topic_score_gemma":0.001378686,"domain_scores_codex":[0.9953734,0.0009501443,0.0003925654,0.0009350983,0.002206866,0.0001419357],"domain_scores_gemma":[0.9988569,0.0002935932,0.0001804556,0.0001005838,0.0005197259,0.00004859643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003627617,0.0004026972,0.003743631,0.0008462719,0.0001680709,0.0003318471,0.0002279542,0.0009954512,0.9238783,0.0009772052,0.0008280351,0.06723787],"study_design_scores_gemma":[0.0001165068,0.001753679,0.008358074,0.0001912916,0.0001902346,0.002464471,0.0001308348,0.00816974,0.9567934,0.0006189879,0.0210971,0.0001156915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3285726,0.02363051,0.6200702,0.001018621,0.0008881928,0.003684889,0.003177651,0.003734214,0.01522319],"genre_scores_gemma":[0.4263023,0.00977718,0.5456595,0.001281125,0.0002330528,0.003758064,0.002769044,0.0001701829,0.01004958],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002222857,"threshold_uncertainty_score":0.0117557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02505392348828441,"score_gpt":0.2949525593858599,"score_spread":0.2698986358975755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}