{"id":"W3008154817","doi":"10.1093/jcag/gwz047.013","title":"A14 GUT-RESIDING BACTERIA CAN SHAPE HOST DRUG METABOLISM IN THE SMALL INTESTINE THROUGH AN INNATE LYMPHOID CELL-IL-22 DRIVEN AXIS","year":2020,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Biology; Drug metabolism; Metabolism; CYP3A4; Cytochrome P450; Innate immune system; Enzyme; Cell biology; Microbiology; Immune system; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001892838,0.0004422113,0.0003103929,0.0002977446,0.0001982676,0.0005336791,0.000168117,0.0004275791,0.002808123],"category_scores_gemma":[0.000139499,0.0001929396,0.0004217676,0.000117968,0.0002909914,0.0002117226,0.0003495475,0.0008045454,0.0008432211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002908128,"about_ca_system_score_gemma":0.0002541848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003765796,"about_ca_topic_score_gemma":0.0006522982,"domain_scores_codex":[0.9997297,0.0000599707,0.00001930615,0.00006268594,0.00005601582,0.00007236911],"domain_scores_gemma":[0.9998311,0.00001382364,0.0000509365,0.00001402608,0.00002176057,0.00006833331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002417815,0.00003032792,0.0008541376,0.00005533043,0.00000597322,0.00008968692,0.00001245149,0.00004998531,0.9970067,0.00008962552,0.00009739489,0.001466698],"study_design_scores_gemma":[0.0001150081,0.002562054,0.06153935,0.00007264951,0.0001095652,0.001238317,0.0004306743,0.002779343,0.9184583,0.0005392074,0.01212871,0.00002684847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856071,0.003415724,0.004903996,0.0005010435,0.00008826131,0.00006647596,0.001321403,0.0002295402,0.003866508],"genre_scores_gemma":[0.9917949,0.001098087,0.003067683,0.0002168285,0.0000305662,0.00006798023,0.0006668365,0.00002813724,0.003028807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002808123,"threshold_uncertainty_score":0.009394109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01152771481073193,"score_gpt":0.2220912362318019,"score_spread":0.21056352142107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}