{"id":"W3008165957","doi":"10.1097/ccm.0000000000004247","title":"Epigenetics of Sepsis","year":2020,"lang":"en","type":"article","venue":"Critical Care Medicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Manitoba; McMaster University; William Osler Health System; Niagara Health System; St. Michael's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Epigenetics; Sepsis; DNA methylation; Medicine; Histone; Immunology; Organ dysfunction; Bioinformatics; Biology; Gene expression; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006257472,0.00008666702,0.0001505414,0.00001615157,0.00002450709,0.00000244326,0.0001011424,0.00008835024,0.0001058461],"category_scores_gemma":[0.001160092,0.00007472705,0.00004616368,0.00008275194,0.0002205689,7.853624e-7,0.00005215251,0.00005565651,0.000004846033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000338488,"about_ca_system_score_gemma":0.00002774376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006139487,"about_ca_topic_score_gemma":0.000001964854,"domain_scores_codex":[0.9992787,0.0000374567,0.0002039507,0.0001977612,0.0001548293,0.0001272839],"domain_scores_gemma":[0.9993695,0.00003601472,0.00002501673,0.0001684463,0.0002392117,0.0001618111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003664932,0.00001619495,0.00712726,0.000218801,0.00001294186,0.000003705525,0.0005361297,0.00002817825,0.9817188,0.0007964058,0.0009388419,0.008566066],"study_design_scores_gemma":[0.0005646467,0.002038237,0.003155367,0.00003182963,0.00007368736,7.706256e-7,0.001455609,0.00008582756,0.9349236,0.0004299154,0.05707723,0.0001633024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8854847,0.0422828,0.04177685,0.01319259,0.000406196,0.0002143347,0.00004470409,0.00002274554,0.01657506],"genre_scores_gemma":[0.9969473,0.0002388668,0.001340713,0.0008357968,0.0005286753,0.000002978729,0.00007099009,0.00001334735,0.00002129694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1114626,"threshold_uncertainty_score":0.3047281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02829052900312425,"score_gpt":0.3260245812846542,"score_spread":0.29773405228153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}