{"id":"W3008167495","doi":"10.1093/noajnl/vdaa020","title":"EGFR blockade in GBM brain tumor stem cells synergizes with JAK2/STAT3 pathway inhibition to abrogate compensatory mechanisms in vitro and in vivo","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Calgary","funders":"Government of Canada; Canadian Institutes of Health Research; Genome Canada; Alberta Cancer Foundation; CTI Biopharma; Stand Up To Cancer","keywords":"Afatinib; In vivo; Cancer research; Neurosphere; Medicine; Pharmacology; In vitro; Viability assay; Erlotinib; Biology; Epidermal growth factor receptor; Internal medicine; Endothelial stem cell; Receptor; Adult stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001653674,0.000427359,0.0004403061,0.0003282152,0.0001371281,0.0002812835,0.0001929895,0.000185708,0.001161665],"category_scores_gemma":[0.00005909144,0.0001073799,0.0003211961,0.0002523019,0.0001294084,0.0001132819,0.0001101017,0.0005761071,0.000337849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002831587,"about_ca_system_score_gemma":0.0003302786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009926033,"about_ca_topic_score_gemma":0.002218987,"domain_scores_codex":[0.9998227,0.00002834116,0.00002277194,0.00001994773,0.00006770042,0.00003855548],"domain_scores_gemma":[0.9999558,0.000007651757,0.000009414434,0.00000635049,0.000006873141,0.00001392554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003181956,0.0002722009,0.0002940068,0.00006482255,0.00002441298,0.00004669069,0.00001703252,0.0003072204,0.9942099,0.00009458629,0.0002156064,0.00413524],"study_design_scores_gemma":[0.00006865348,0.001506783,0.003246603,0.000004859083,0.00003312263,0.0001702031,0.00001507031,0.001309983,0.9920698,0.00003527238,0.001536019,0.000003532713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942451,0.001523846,0.001618711,0.0001117316,0.00004519758,0.00006966905,0.0007281509,0.0001266013,0.001530968],"genre_scores_gemma":[0.9961833,0.0007562422,0.001144245,0.00004535623,0.000009968288,0.00007410647,0.0008625255,0.000009713889,0.0009144024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001161665,"threshold_uncertainty_score":0.003886163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0110308927171843,"score_gpt":0.2476797498927438,"score_spread":0.2366488571755595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}