{"id":"W3008193003","doi":"10.1126/scisignal.aax8295","title":"SMAC mimetics and RIPK inhibitors as therapeutics for chronic inflammatory diseases","year":2020,"lang":"en","type":"review","venue":"Science Signaling","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"","keywords":"Medicine; Inflammation; Pharmacology; Computational biology; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004103867,0.0003875153,0.001030851,0.0003602804,0.0004186347,0.0001718931,0.0002654258,0.0001427607,0.00005707988],"category_scores_gemma":[0.0003583221,0.0003022425,0.0004405736,0.0007111378,0.0005511706,0.0001665725,0.0001256827,0.0004596707,0.00003520527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003591154,"about_ca_system_score_gemma":0.003573315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005098945,"about_ca_topic_score_gemma":8.455444e-7,"domain_scores_codex":[0.9977058,0.00003826764,0.0005991299,0.0006828153,0.0004759464,0.0004980535],"domain_scores_gemma":[0.998474,0.0003122678,0.0003206119,0.000310847,0.0002153286,0.0003669561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001947102,0.00005373599,0.00001405749,0.009788912,0.000169255,0.00002607792,0.0002233136,0.000005894495,0.005306511,0.0008671292,0.000129229,0.9833964],"study_design_scores_gemma":[0.0002821505,0.0004615513,0.000001571754,0.009726305,0.001721453,0.00009510059,0.00008662951,0.0003583239,0.001629833,0.0001732704,0.9851341,0.0003297382],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002737225,0.9971232,0.0002903565,0.0001648465,0.0005956863,0.001221976,0.00007745653,0.00009735546,0.0001553822],"genre_scores_gemma":[0.002382204,0.9952965,0.0004237769,0.0002434307,0.001336482,0.0001124004,0.00004841707,0.00007078111,0.00008596655],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9850048,"threshold_uncertainty_score":0.999943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05882543345424149,"score_gpt":0.3792187068947981,"score_spread":0.3203932734405566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}