{"id":"W3008199088","doi":"10.1016/j.heares.2020.107930","title":"Preclinical testing of AAV9-PHP.B for transgene expression in the non-human primate cochlea","year":2020,"lang":"en","type":"article","venue":"Hearing Research","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Nuclear Laboratories","funders":"National Institute on Deafness and Other Communication Disorders; National Institute of Neurological Disorders and Stroke; National Eye Institute; National Institutes of Health","keywords":"Transduction (biophysics); Transgene; Cochlea; Inner ear; Biology; Genetic enhancement; Adeno-associated virus; Capsid; Hair cell; Round window; Viral vector; Callithrix; Cell biology; Reporter gene; Gene delivery; Green fluorescent protein; Primate; Molecular biology; Vector (molecular biology); Gene; Gene expression; Virology; Virus; Anatomy; Genetics; Neuroscience; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002428186,0.001721942,0.0008578026,0.0009635607,0.0008891273,0.001374991,0.001284428,0.00176111,0.006360258],"category_scores_gemma":[0.0009770823,0.000494606,0.000739838,0.000347759,0.001235068,0.001238555,0.0003662017,0.003264821,0.001931879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008128893,"about_ca_system_score_gemma":0.001910648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00356483,"about_ca_topic_score_gemma":0.005771714,"domain_scores_codex":[0.9990819,0.0001749993,0.00006073518,0.000207571,0.0002147802,0.0002600871],"domain_scores_gemma":[0.9990262,0.0002155529,0.0001464681,0.0001236041,0.0001963298,0.0002918486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003034292,0.003461982,0.0002504805,0.0002686472,0.00006678561,0.0003755003,0.0002597805,0.0006110299,0.9796845,0.001465156,0.001677074,0.008844842],"study_design_scores_gemma":[0.0009907945,0.04534329,0.001985944,0.000125728,0.000235894,0.001171403,0.0003487614,0.0024016,0.9302357,0.001142167,0.01597948,0.00003928428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.916302,0.006774807,0.04615659,0.001542696,0.001163535,0.004356945,0.004490108,0.001625188,0.01758811],"genre_scores_gemma":[0.9455971,0.005283842,0.02214468,0.0005819076,0.0001720278,0.003115647,0.004200828,0.0003637258,0.01854026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006360258,"threshold_uncertainty_score":0.02127719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5708061599228988,"score_gpt":0.5404141317305243,"score_spread":0.03039202819237452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}