{"id":"W3008218959","doi":"10.1093/jcag/gwz047.034","title":"A35 MICROBIAL PROTEOLYTIC SIGNATURE IN ULCERATIVE COLITIS INDUCES AN INFLAMMATORY SIGNATURE IN MICROBIOTA-HUMANIZED MICE","year":2020,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; University of Toronto; McMaster University; Population Health Research Institute","funders":"","keywords":"Proteases; Ulcerative colitis; Dysbiosis; Feces; Metagenomics; Biology; Calprotectin; Immunology; Microbiome; Colitis; Neutrophil elastase; Microbiology; Gut flora; Elastase; Inflammatory bowel disease; Proteolytic enzymes; Inflammation; Medicine; Internal medicine; Bioinformatics; Gene; Enzyme; Genetics; Disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004287503,0.0005412545,0.0005200194,0.001094895,0.0003201301,0.0005343299,0.0002346371,0.0006904799,0.003163746],"category_scores_gemma":[0.0003916705,0.0004593782,0.000688736,0.0004528257,0.0005398289,0.0003127595,0.0005033296,0.001503573,0.0006867645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003256866,"about_ca_system_score_gemma":0.0002923813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005404459,"about_ca_topic_score_gemma":0.0007317519,"domain_scores_codex":[0.9993634,0.0001014553,0.0000528179,0.0002226429,0.0001235388,0.0001362086],"domain_scores_gemma":[0.9993129,0.00005680439,0.0002479546,0.00008415217,0.00004066617,0.0002576049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001645102,0.0002410592,0.002488081,0.00007462705,0.00003460007,0.0002073353,0.00007110708,0.00007698362,0.9929443,0.00009030087,0.0001444953,0.001982123],"study_design_scores_gemma":[0.0005301514,0.009374342,0.2904833,0.0001663751,0.0002935139,0.005336793,0.0007577053,0.003377716,0.6788282,0.0007157044,0.0100516,0.00008462843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925871,0.001114485,0.002530218,0.0002297745,0.00005234428,0.00005902358,0.002390571,0.0001797672,0.0008567278],"genre_scores_gemma":[0.9904183,0.000729816,0.003349126,0.0003364091,0.00002453564,0.0001726709,0.002381274,0.0001056856,0.002482241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003163746,"threshold_uncertainty_score":0.01058382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005106644990058073,"score_gpt":0.2029222197277745,"score_spread":0.1978155747377164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}