{"id":"W3008222032","doi":"10.3390/jcm9030616","title":"Neuropathophysiology of Lysosomal Storage Diseases: Synaptic Dysfunction as a Starting Point for Disease Progression","year":2020,"lang":"en","type":"review","venue":"Journal of Clinical Medicine","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Fonds de recherche du Québec","keywords":"Neuroscience; Synaptic cleft; Medicine; Neurotransmission; Postsynaptic potential; Neurodegeneration; Synaptic vesicle; Disease; Synaptic plasticity; Biogenesis; Biology; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002380446,0.0005476143,0.006849732,0.0004678533,0.00007685619,0.00001088562,0.000464567,0.0004088618,0.0002305915],"category_scores_gemma":[0.05228388,0.0003223796,0.002425993,0.000586847,0.0006318526,0.0001300595,0.0001880246,0.001896183,0.00002128876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001516167,"about_ca_system_score_gemma":0.002761543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003195487,"about_ca_topic_score_gemma":2.235256e-7,"domain_scores_codex":[0.9907824,0.001258901,0.00536168,0.0006194227,0.001496834,0.0004807238],"domain_scores_gemma":[0.9872001,0.004372783,0.0049676,0.0005487308,0.001128122,0.001782701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007671018,0.001003088,0.0003403585,0.03940728,0.0009245498,0.002855123,0.00004122651,0.000001329953,0.000019734,0.00003071583,0.001779402,0.9459262],"study_design_scores_gemma":[0.01516293,0.05423278,0.001646169,0.1280903,0.02261197,0.0007285782,0.0002040724,0.000605753,0.000001102183,0.001979387,0.7741487,0.0005882648],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002506289,0.9894253,0.000581498,0.003409607,0.001557695,0.002363965,0.0000508876,0.00002900592,0.00007577824],"genre_scores_gemma":[0.005645954,0.9876147,0.0003816775,0.0006469518,0.005359562,0.00006652734,0.00009396833,0.0001276465,0.00006304107],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9453379,"threshold_uncertainty_score":0.9999228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1108770728582582,"score_gpt":0.4840226800013716,"score_spread":0.3731456071431133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}