{"id":"W3008229139","doi":"10.1093/jcag/gwz047.053","title":"A54 DELTA OPIOID RECEPTOR SIGNALING MEDIATES OPIOID INDUCED TOLERANCE AND HYPERALGESIA IN COLONIC SENSORY NERVES","year":2020,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Naltrindole; Hyperalgesia; Morphine; Opioid; Medicine; μ-opioid receptor; Pharmacology; Nociception; Anesthesia; Opioid receptor; Drug tolerance; Neuropathic pain; Antagonist; Receptor antagonist; Analgesic; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007853706,0.0002419875,0.0002589737,0.0001259718,0.000194313,0.0002658901,0.0001490743,0.0002534873,0.002665749],"category_scores_gemma":[0.00007709625,0.0001189133,0.0003327771,0.00008119349,0.0001764084,0.0002253014,0.0001940652,0.0005672741,0.0004877788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002027778,"about_ca_system_score_gemma":0.0001647896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004424078,"about_ca_topic_score_gemma":0.000546158,"domain_scores_codex":[0.99991,0.000008452004,0.000006789148,0.00001847812,0.00002107164,0.00003520923],"domain_scores_gemma":[0.9999143,0.000005661793,0.00002777795,0.000006617906,0.00001285267,0.00003275015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001648216,0.00002178812,0.0005993274,0.0000437015,0.000004429672,0.00008499278,0.000007042021,0.00001765678,0.9981685,0.00004755266,0.00003422696,0.0008059735],"study_design_scores_gemma":[0.00009126568,0.003079072,0.1908117,0.0001085504,0.00008011659,0.002482868,0.0003552866,0.001952727,0.796288,0.0004351983,0.004294131,0.00002113937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943945,0.002471919,0.001337569,0.0001454211,0.00002754889,0.00001623821,0.0003226275,0.00003372536,0.001250524],"genre_scores_gemma":[0.9954875,0.001682095,0.0005117144,0.00009123534,0.00001294281,0.00002153607,0.0003087794,0.00000486831,0.001879283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002665749,"threshold_uncertainty_score":0.008917868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01577898061275881,"score_gpt":0.2319341306576853,"score_spread":0.2161551500449265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}