{"id":"W3008259997","doi":"10.1038/s41523-020-0148-0","title":"The Prosigna 50-gene profile and responsiveness to adjuvant anthracycline-based chemotherapy in high-risk breast cancer patients","year":2020,"lang":"en","type":"article","venue":"npj Breast Cancer","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Epirubicin; Cyclophosphamide; Internal medicine; Oncology; Anthracycline; Hazard ratio; Breast cancer; Chemotherapy; Adjuvant chemotherapy; Fluorouracil; Clinical endpoint; Proportional hazards model; Adjuvant; Methotrexate; Randomized controlled trial; Cancer; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001157973,0.0003552423,0.0003314429,0.00004118316,0.000246156,0.00004521898,0.0002422293,0.0001223839,0.00006828576],"category_scores_gemma":[0.00003213,0.000261054,0.00007162864,0.0002532731,0.0001673401,0.00001111415,0.0001454889,0.0001439317,0.00000718896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001474172,"about_ca_system_score_gemma":0.0003110144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002552492,"about_ca_topic_score_gemma":0.001294683,"domain_scores_codex":[0.9981129,0.0001252688,0.0003010553,0.0007346626,0.0002524837,0.000473614],"domain_scores_gemma":[0.9990304,0.00003748917,0.0001616491,0.0003185828,0.0002462336,0.0002056806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009250366,0.0002609169,0.8294933,0.00005499015,0.0001897113,0.000004395481,0.0003189212,0.0003619883,0.0367825,0.000004066579,0.001946478,0.1213323],"study_design_scores_gemma":[0.004262018,0.0001871279,0.9451895,0.0000742699,0.00005113958,0.00000537152,0.00005720999,0.00006349866,0.04613006,0.000006838528,0.003634784,0.000338231],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721047,0.002297104,0.00005700024,0.02102817,0.0002325049,0.0008729059,0.003363349,0.00002671461,0.00001751874],"genre_scores_gemma":[0.9936405,0.00138446,0.0001588278,0.003056374,0.0004879141,0.001078746,0.00008681735,0.00006511561,0.0000412727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1209941,"threshold_uncertainty_score":0.9999841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006323787954146343,"score_gpt":0.2503081837815237,"score_spread":0.2439843958273774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}