{"id":"W3008322752","doi":"10.1126/sciadv.aay5064","title":"PHOTACs enable optical control of protein degradation","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":298,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; National Cancer Institute; New York University; York University; Howard Hughes Medical Institute","keywords":"Degradation (telecommunications); Protein degradation; Modular design; Computer science; Control (management); Biophysics; Chemistry; Cell biology; Biology; Biochemistry; Telecommunications; Artificial intelligence","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001741137,0.0002893592,0.0001478344,0.0001401788,0.0001472199,0.0003366206,0.0002916513,0.0003758058,0.001513466],"category_scores_gemma":[0.000153166,0.0001546207,0.0001943299,0.0001421659,0.0003016781,0.0003121113,0.0003282239,0.0006321543,0.0003094105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000408593,"about_ca_system_score_gemma":0.0002055548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000294092,"about_ca_topic_score_gemma":0.0003942831,"domain_scores_codex":[0.9998573,0.00001307506,0.00000777398,0.00004710733,0.00004947707,0.00002526892],"domain_scores_gemma":[0.9999007,0.00001983656,0.00003807437,0.00001397201,0.00001167573,0.00001574399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004342065,0.000009310023,0.00003990199,0.00002873685,0.000003071517,0.00001825035,0.000009619791,0.0001263282,0.9948742,0.001351114,0.0001258338,0.003370217],"study_design_scores_gemma":[0.000007033816,0.00004712462,0.0001560225,0.000001573515,0.00000216465,0.00006383567,0.000003577639,0.0006935424,0.9957132,0.0001084544,0.003200359,0.000003179885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8711758,0.003202294,0.1089163,0.0005600354,0.0001994213,0.0001216129,0.0006682517,0.00131467,0.01384163],"genre_scores_gemma":[0.9675072,0.001193354,0.02560431,0.0001821826,0.00002369296,0.00008272268,0.0001972826,0.00006693435,0.005142406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001513466,"threshold_uncertainty_score":0.005062997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009361328203190755,"score_gpt":0.2499912143661777,"score_spread":0.240629886162987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}