{"id":"W3008338337","doi":"10.1101/2020.02.23.959932","title":"Specialized DNA structures act as genomic beacons for integration by evolutionarily diverse retroviruses","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Provirus; Genome; Genetics; DNA; Retrovirus; Integrase; Gene; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000380379,0.0003137501,0.0002875098,0.0008707726,0.0001951115,0.0004507525,0.0003339613,0.0005102003,0.0008093239],"category_scores_gemma":[0.0005081311,0.0003359669,0.0002947716,0.0004828525,0.0003859125,0.0003449015,0.0004681795,0.0005639599,0.0003420511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002683336,"about_ca_system_score_gemma":0.0001107579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002303255,"about_ca_topic_score_gemma":0.0003705874,"domain_scores_codex":[0.9996675,0.00006714016,0.00001623087,0.0001248956,0.00007156582,0.00005265345],"domain_scores_gemma":[0.9994848,0.0001457201,0.0001977815,0.00005515332,0.00004853506,0.00006809032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005315538,0.000006926922,0.0008195692,0.00002422308,0.00000570482,0.00002017654,0.00002603172,0.00008107895,0.9972778,0.0001741213,0.00001488843,0.001496395],"study_design_scores_gemma":[0.00002227432,0.0003743923,0.02519443,0.00002099434,0.00003373817,0.0005520633,0.0001028766,0.002283781,0.9679825,0.0005408612,0.002877577,0.00001451108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9655419,0.001923399,0.03061273,0.0000437732,0.00002164006,0.00004019392,0.0002767523,0.0002506418,0.001288857],"genre_scores_gemma":[0.9762232,0.0003938299,0.02174108,0.00009267213,0.00001328834,0.00003985418,0.0006617763,0.00004703872,0.000787332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008707726,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01270849733285875,"score_gpt":0.2609521410229225,"score_spread":0.2482436436900637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}