{"id":"W3008374819","doi":"10.1016/j.lungcan.2020.02.016","title":"A phase IB study of durvalumab with or without tremelimumab and platinum-doublet chemotherapy in advanced solid tumours: Canadian Cancer Trials Group Study IND226","year":2020,"lang":"en","type":"article","venue":"Lung Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; Princess Margaret Cancer Centre; BC Cancer Agency; Cancer Care South East; McMaster University; Queen's University; Centre Hospitalier de l’Université de Montréal; University of Calgary; Juravinski Cancer Centre","funders":"Canadian Cancer Society Research Institute","keywords":"Medicine; Internal medicine; Carboplatin; Durvalumab; Tremelimumab; Chemotherapy; Gemcitabine; Pemetrexed; Pneumonitis; Lung cancer; Oxaliplatin; Gastroenterology; Oncology; Surgery; Cancer; Cisplatin; Pembrolizumab; Immunotherapy; Ipilimumab; Colorectal cancer; Lung","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001941735,0.002015338,0.00296118,0.0005453182,0.0006977082,0.001508772,0.001411104,0.001505545,0.006288775],"category_scores_gemma":[0.001158902,0.0007355823,0.002264501,0.0007459611,0.00142693,0.0009797319,0.0004257596,0.004149722,0.001474363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002767918,"about_ca_system_score_gemma":0.004437545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01306837,"about_ca_topic_score_gemma":0.03872715,"domain_scores_codex":[0.999416,0.0002561263,0.0000191077,0.00008961371,0.00006125268,0.0001579418],"domain_scores_gemma":[0.9992124,0.0001001777,0.0001093227,0.00007111743,0.0000373813,0.000469589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8909807,0.02737231,0.002098056,0.0009347847,0.002229396,0.0001075539,0.0002330993,0.001911942,0.0132066,0.0004865962,0.007003174,0.05343583],"study_design_scores_gemma":[0.8410654,0.1454555,0.006000089,0.00003638718,0.0009141164,0.0001456984,0.0000628246,0.0005976011,0.001239695,0.0002404031,0.004203119,0.00003927374],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769557,0.005325614,0.0006974456,0.001356431,0.0004271089,0.003697285,0.006125777,0.0001939021,0.005220825],"genre_scores_gemma":[0.9681322,0.006112018,0.002646155,0.001699115,0.0003627901,0.003501203,0.008047512,0.0001048429,0.009394185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01306837,"threshold_uncertainty_score":0.02598464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05066850904979687,"score_gpt":0.3948271485646301,"score_spread":0.3441586395148333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}