{"id":"W3008374819","doi":"10.1016/j.lungcan.2020.02.016","title":"A phase IB study of durvalumab with or without tremelimumab and platinum-doublet chemotherapy in advanced solid tumours: Canadian Cancer Trials Group Study IND226","year":2020,"lang":"en","type":"article","venue":"Lung Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; Princess Margaret Cancer Centre; BC Cancer Agency; Cancer Care South East; McMaster University; Queen's University; Centre Hospitalier de l’Université de Montréal; University of Calgary; Juravinski Cancer Centre","funders":"Canadian Cancer Society Research Institute","keywords":"Medicine; Internal medicine; Carboplatin; Durvalumab; Tremelimumab; Chemotherapy; Gemcitabine; Pemetrexed; Pneumonitis; Lung cancer; Oxaliplatin; Gastroenterology; Oncology; Surgery; Cancer; Cisplatin; Pembrolizumab; Immunotherapy; Ipilimumab; Colorectal cancer; Lung","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006010929,0.0003924105,0.001484672,0.000238665,0.00009298524,0.00003747324,0.0001663852,0.00009280128,0.0006964994],"category_scores_gemma":[0.00005542509,0.0002741041,0.00007566296,0.0008245649,0.00009304477,0.0001602873,0.00002343902,0.0002933399,5.170745e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005731597,"about_ca_system_score_gemma":0.001323545,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.1901607,"about_ca_topic_score_gemma":0.6798894,"domain_scores_codex":[0.9973355,0.0002153373,0.0008511196,0.000650542,0.0004744673,0.0004730495],"domain_scores_gemma":[0.998719,0.00008415563,0.0003949165,0.0003391709,0.0001166584,0.0003460557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1758902,0.003936703,0.6536161,0.0003299468,0.002310294,0.0002510186,0.06066004,0.0000998352,0.0130111,0.000001302954,0.0007282436,0.08916522],"study_design_scores_gemma":[0.5800319,0.05134458,0.2987964,0.002018807,0.00201201,0.00003857976,0.05223447,0.002769897,0.005040956,0.00000251198,0.004287179,0.001422749],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989626,0.002729361,0.000008148533,0.001595057,0.0001580976,0.005633015,0.000105598,0.00004217264,0.0001025894],"genre_scores_gemma":[0.9961277,0.0006396206,0.00008386815,0.001708485,0.0002288457,0.0009491887,0.00001116043,0.00008133094,0.0001698185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4897287,"threshold_uncertainty_score":0.9999711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05066850904979687,"score_gpt":0.3948271485646301,"score_spread":0.3441586395148333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}