{"id":"W3008389809","doi":"10.1093/jcag/gwz047.126","title":"A127 THE ROLE OF ENDOGENOUS OPIOIDS IN MITIGATING OPIOID TOLERANCE IN A PRE-CLINICAL MODEL OF IBD","year":2020,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Medicine; Morphine; Chronic pain; Pharmacology; Opioid; Neuropathic pain; Endogenous opioid; Endogeny; Analgesic; Drug tolerance; Nociception; μ-opioid receptor; Colitis; Anesthesia; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001571125,0.0003590442,0.000395353,0.0002747634,0.0001609924,0.0003010767,0.0001915321,0.0003869197,0.003373783],"category_scores_gemma":[0.0001345725,0.0001286505,0.000296639,0.0001579906,0.0002483475,0.0002892097,0.0001571038,0.001135037,0.0004729225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001789213,"about_ca_system_score_gemma":0.0002624802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003336046,"about_ca_topic_score_gemma":0.0005667296,"domain_scores_codex":[0.9998728,0.00001811101,0.00001049773,0.00002172666,0.0000379091,0.00003896106],"domain_scores_gemma":[0.9998739,0.00001070157,0.00003343503,0.00001170896,0.00002005284,0.00005017344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00276684,0.0007519079,0.0006436314,0.0002975081,0.00001531833,0.0001153212,0.0000222475,0.00007962114,0.9836158,0.000123329,0.0002394554,0.01132888],"study_design_scores_gemma":[0.000876803,0.0446608,0.05538654,0.0002021212,0.0001709284,0.001322442,0.0002710893,0.002342925,0.8792663,0.0003410491,0.01513196,0.00002710251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879083,0.006973014,0.001653981,0.0004392757,0.0001920661,0.0001291955,0.0006915514,0.00009055401,0.001921965],"genre_scores_gemma":[0.9883537,0.004017952,0.00180382,0.0001778522,0.00006150068,0.00017302,0.0006692227,0.000011709,0.00473106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003373783,"threshold_uncertainty_score":0.01128638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02370597281248306,"score_gpt":0.2581949419710193,"score_spread":0.2344889691585362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}