{"id":"W3008401112","doi":"10.3389/fncel.2020.00036","title":"Depolarizing GABA Transmission Restrains Activity-Dependent Glutamatergic Synapse Formation in the Developing Hippocampal Circuit","year":2020,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; University of Toronto; Montreal General Hospital","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Neuroscience; Depolarization; Glutamatergic; GABAA receptor; Synapse; Neurotransmission; Inhibitory postsynaptic potential; Excitatory postsynaptic potential; Excitatory synapse; Hippocampal formation; Biology; Chemistry; Glutamate receptor; Biophysics; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008802204,0.0003135901,0.0004407022,0.0002066099,0.0001616002,0.0003875698,0.0002752064,0.0002162581,0.000647434],"category_scores_gemma":[0.0001727845,0.0002696701,0.0002758206,0.0001391205,0.0003039843,0.0002772527,0.000361799,0.0008976361,0.0001961714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004463645,"about_ca_system_score_gemma":0.0003925337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001254247,"about_ca_topic_score_gemma":0.002332947,"domain_scores_codex":[0.9998717,0.00001000525,0.00002012193,0.00003355205,0.00002886754,0.00003572708],"domain_scores_gemma":[0.9998747,0.0000216681,0.00003287872,0.00001800951,0.00001760813,0.00003505123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003128764,0.000005095997,0.0001596496,0.00002236821,0.0000032945,0.00003678143,0.0000163292,0.00004172941,0.9990702,0.00004872274,0.000007142513,0.0005573037],"study_design_scores_gemma":[0.000008713028,0.0002124211,0.0129697,0.00001036341,0.00002447113,0.0002164679,0.00006209964,0.0005675508,0.985042,0.00009027157,0.0007879771,0.000008045564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959862,0.001516708,0.001523133,0.00005861602,0.00002073422,0.0000131582,0.0001278644,0.00004878673,0.0007047681],"genre_scores_gemma":[0.9967951,0.001195366,0.001106237,0.00005619064,0.000006794779,0.00002548425,0.0001548021,0.00002391402,0.0006362417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001254247,"threshold_uncertainty_score":0.003238618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08975241314007489,"score_gpt":0.3019245846329901,"score_spread":0.2121721714929152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}