{"id":"W3008407397","doi":"10.1074/jbc.ra120.012546","title":"Chronic wasting disease (CWD) prion strains evolve via adaptive diversification of conformers in hosts expressing prion protein polymorphisms","year":2020,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; Alberta Prion Research Institute; Natural Sciences and Engineering Research Council of Canada; Alberta Innovates Bio Solutions; Foundation for the National Institutes of Health","keywords":"Chronic wasting disease; Biology; Enzootic; Conformational isomerism; Phenotype; Virology; Prion protein; Genetics; Virus; Gene; Scrapie; Disease; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000323234,0.0002018677,0.0001567834,0.0002844325,0.0001839871,0.0003983006,0.0001764222,0.0002835823,0.0004342795],"category_scores_gemma":[0.0004159394,0.0001150307,0.0001233594,0.0002262278,0.0002750428,0.0002863999,0.0003344979,0.000438612,0.0001440994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001983576,"about_ca_system_score_gemma":0.0000981768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002748443,"about_ca_topic_score_gemma":0.0005514859,"domain_scores_codex":[0.999874,0.00003236267,0.00001138935,0.00003177669,0.00002273119,0.00002765044],"domain_scores_gemma":[0.9997827,0.00004603728,0.00008276893,0.00002648902,0.00002641954,0.00003557424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002303585,0.00006931527,0.02259173,0.00002712805,0.00003432002,0.0003148057,0.0001492547,0.000317972,0.9686971,0.0007998719,0.00008825252,0.006679819],"study_design_scores_gemma":[0.0001463165,0.002929556,0.6969102,0.00006631697,0.0001856,0.0124942,0.001102908,0.01772139,0.2566126,0.005315789,0.00639263,0.0001224711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989433,0.0001275453,0.0006137339,0.00002204093,0.000003165435,0.00000417874,0.00003042696,0.000007431019,0.000248216],"genre_scores_gemma":[0.9990964,0.0001129622,0.0004941032,0.00002091178,0.000003460628,0.000003230734,0.00007124513,0.000004994523,0.0001926767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004342795,"threshold_uncertainty_score":0.001709461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02960833052724861,"score_gpt":0.2489687897958868,"score_spread":0.2193604592686382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}