{"id":"W3008501255","doi":"10.1093/nar/gkaa127","title":"Long noncoding RNA HCP5 participates in premature ovarian insufficiency by transcriptionally regulating MSH5 and DNA damage repair via YB1","year":2020,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Biology; Long non-coding RNA; Gene silencing; Epigenetics; DNA damage; DNA repair; Genetics; Transcription factor; Cell biology; Premature ovarian failure; Gene; RNA; DNA; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001416844,0.0002365223,0.0002554482,0.0001730739,0.0002810075,0.0001223783,0.0004566323,0.0003944494,0.0001476973],"category_scores_gemma":[0.0005541628,0.000246554,0.0001065773,0.0007858389,0.0002722559,0.00002557046,0.0004273465,0.0009508863,0.00001582595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009099438,"about_ca_system_score_gemma":0.0002108246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008714225,"about_ca_topic_score_gemma":0.0001056067,"domain_scores_codex":[0.9964125,0.0004733108,0.0004052857,0.0009113139,0.0008958778,0.0009017718],"domain_scores_gemma":[0.9988108,0.00005388755,0.00005538965,0.000456864,0.0002424567,0.0003805481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003060194,0.0001277757,0.0005508647,0.0001269422,0.00004459163,0.00005262866,0.0007023716,0.0001455408,0.9937706,0.0001549884,0.001831316,0.002186351],"study_design_scores_gemma":[0.00296544,0.002265783,0.009839498,0.0002311445,0.00002459933,0.00004054033,0.000828021,0.04370305,0.9274348,0.0003082693,0.01161858,0.000740248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872012,0.001571535,0.006507146,0.00224819,0.00004757255,0.000693824,0.00003359124,0.00005834036,0.001638581],"genre_scores_gemma":[0.9975805,0.0002194421,0.001254032,0.0002571125,0.0001746096,0.00007354106,0.00009730286,0.00006964445,0.0002737804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06633578,"threshold_uncertainty_score":0.9999987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03208886189430093,"score_gpt":0.3147652670253628,"score_spread":0.2826764051310618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}