{"id":"W3008501255","doi":"10.1093/nar/gkaa127","title":"Long noncoding RNA HCP5 participates in premature ovarian insufficiency by transcriptionally regulating MSH5 and DNA damage repair via YB1","year":2020,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Biology; Long non-coding RNA; Gene silencing; Epigenetics; DNA damage; DNA repair; Genetics; Transcription factor; Cell biology; Premature ovarian failure; Gene; RNA; DNA; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000105665,0.0002046212,0.0001536887,0.0002108885,0.0001663061,0.0002232245,0.0001302613,0.0001987548,0.0007889479],"category_scores_gemma":[0.0001399954,0.00008450056,0.0001914625,0.0001117345,0.0002660765,0.0001310973,0.0002688179,0.0002363933,0.00008782794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002433669,"about_ca_system_score_gemma":0.0001953271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005679714,"about_ca_topic_score_gemma":0.0006795375,"domain_scores_codex":[0.9999191,0.00001071124,0.000008902707,0.0000222415,0.00002167344,0.00001732806],"domain_scores_gemma":[0.9999194,0.000009516991,0.00003410812,0.000006686161,0.000007524389,0.00002277362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002012076,0.000007469567,0.006096213,0.00007757309,0.00001817537,0.0005788472,0.00005596291,0.00009184356,0.9893924,0.0003233535,0.00004675305,0.003110186],"study_design_scores_gemma":[0.00003663916,0.0002438904,0.105033,0.00003438889,0.00009946382,0.00217129,0.0002492271,0.002174561,0.883193,0.0005302969,0.006221349,0.00001287469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927608,0.003586994,0.002759356,0.0001150329,0.00002399225,0.000008668963,0.0001888125,0.00003596507,0.0005204844],"genre_scores_gemma":[0.9981933,0.0004538821,0.0006169479,0.00004129014,0.000005014223,0.000005205998,0.0001285507,0.000004392502,0.000551425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007889479,"threshold_uncertainty_score":0.002639353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03208886189430093,"score_gpt":0.3147652670253628,"score_spread":0.2826764051310618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}