{"id":"W3008528924","doi":"10.1053/j.gastro.2020.02.030","title":"Efficacy of Upadacitinib in a Randomized Trial of Patients With Active Ulcerative Colitis","year":2020,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":277,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Janssen Biotech; Atlantic Healthcare; AbbVie; Genentech; Celgene; Gilead Sciences; Amgen; Pfizer; Takeda Pharmaceutical Company; Eli Lilly and Company","keywords":"Medicine; Placebo; Ulcerative colitis; Discontinuation; Gastroenterology; Internal medicine; Clinical endpoint; Surgery; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003147471,0.001331957,0.002757611,0.0003721375,0.0004483141,0.001000772,0.0006811484,0.001474549,0.004485701],"category_scores_gemma":[0.002844104,0.0007418232,0.00156547,0.0003805457,0.00094816,0.000873672,0.0004952803,0.002378741,0.0005048799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005573215,"about_ca_system_score_gemma":0.0008834553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004883801,"about_ca_topic_score_gemma":0.001119577,"domain_scores_codex":[0.9983405,0.00111472,0.0001003333,0.0001972069,0.00009464598,0.0001526085],"domain_scores_gemma":[0.9984179,0.0004494118,0.00049198,0.0001144866,0.0001139224,0.0004123301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9877234,0.001979958,0.0006648797,0.0003884424,0.0007650208,0.0000280356,0.00002305007,0.0001461295,0.0008375302,0.00004955541,0.0003431728,0.007050869],"study_design_scores_gemma":[0.9723802,0.02468376,0.001599005,0.00002406896,0.0004374331,0.00002386117,0.00001036438,0.0002750494,0.0001262152,0.00006982615,0.0003632822,0.0000069361],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796733,0.01136953,0.0005903285,0.001191679,0.0008844892,0.00344497,0.0006239772,0.00009591589,0.002125688],"genre_scores_gemma":[0.9914514,0.002568003,0.0007086566,0.0008524763,0.0004377355,0.002311225,0.0005592126,0.00001039139,0.001100778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004485701,"threshold_uncertainty_score":0.01664561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005645526338308762,"score_gpt":0.2207515234750673,"score_spread":0.2151059971367586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}