{"id":"W3008569505","doi":"10.3390/cancers12030531","title":"Reduced SKP1 Expression Induces Chromosome Instability through Aberrant Cyclin E1 Protein Turnover","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Strong; University of Bristol; University of Manitoba; Natural Sciences and Engineering Research Council of Canada; CancerCare Manitoba Foundation","keywords":"Gene silencing; Ubiquitin ligase; Biology; Skp1; Genetics; Gene; Chromosome instability; Genome instability; Cyclin B; Cell cycle; Cyclin; Chromosome; Cyclin A; Cyclin D; Cell biology; Ubiquitin; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009027979,0.0001921896,0.0001873654,0.000009914118,0.00006735398,0.00001980415,0.0002539598,0.0002000418,0.0001241118],"category_scores_gemma":[0.0001381344,0.0001752344,0.0001017641,0.0001118212,0.00008745351,0.00001222568,0.0001504913,0.0001576163,0.00001938098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001597764,"about_ca_system_score_gemma":0.0003946895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006417714,"about_ca_topic_score_gemma":0.0000145156,"domain_scores_codex":[0.9986763,0.00006934465,0.0002245978,0.0005794897,0.0001795829,0.0002706865],"domain_scores_gemma":[0.9993044,0.000004503708,0.000105228,0.0003969148,0.00005119714,0.0001378035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001367479,0.00001364741,0.00002733978,0.00004212351,0.00002153507,0.000004079674,0.0003725313,0.00008541105,0.9972494,0.00002852337,0.001489038,0.0005296371],"study_design_scores_gemma":[0.0005271069,0.0002536805,0.00009076685,0.00004052614,0.000008230204,0.000001892612,0.0001545927,0.00004141885,0.9765725,0.00014874,0.02193618,0.0002244203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963551,0.0004858456,0.000298435,0.0004669368,0.0002446536,0.0004853742,0.00003087422,0.00005214021,0.001580678],"genre_scores_gemma":[0.9970927,0.0000350089,0.001314946,0.0007963949,0.0003955481,0.0001146413,0.00005087125,0.00003185857,0.0001679868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02067694,"threshold_uncertainty_score":0.7145851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02362072498324339,"score_gpt":0.2653384980069503,"score_spread":0.2417177730237069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}