{"id":"W3008569505","doi":"10.3390/cancers12030531","title":"Reduced SKP1 Expression Induces Chromosome Instability through Aberrant Cyclin E1 Protein Turnover","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Strong; University of Bristol; University of Manitoba; Natural Sciences and Engineering Research Council of Canada; CancerCare Manitoba Foundation","keywords":"Gene silencing; Ubiquitin ligase; Biology; Skp1; Genetics; Gene; Chromosome instability; Genome instability; Cyclin B; Cell cycle; Cyclin; Chromosome; Cyclin A; Cyclin D; Cell biology; Ubiquitin; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001081961,0.0002002741,0.0001705703,0.0002698581,0.0001139129,0.0002347631,0.0001017516,0.0001549265,0.001016052],"category_scores_gemma":[0.00009959612,0.0001174724,0.0001536915,0.0001724112,0.0001958772,0.00008731362,0.0001799171,0.0002525657,0.0001902972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002623869,"about_ca_system_score_gemma":0.0001538199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006238216,"about_ca_topic_score_gemma":0.00118112,"domain_scores_codex":[0.9999321,0.000007418326,0.000005337964,0.00002399186,0.00001836183,0.00001283826],"domain_scores_gemma":[0.9999352,0.00001712221,0.00002234286,0.000008689569,0.000005983582,0.00001076409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004672524,0.000006314046,0.0009564165,0.0000173608,0.000005367085,0.00003561,0.000007353741,0.00007519172,0.9979457,0.00005591597,0.00001673602,0.0008312241],"study_design_scores_gemma":[0.000006402262,0.0001792338,0.02664048,0.000003378285,0.00001819002,0.00039051,0.00002809682,0.001155897,0.9698476,0.0000654391,0.001661643,0.000003272149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995787,0.000674107,0.002324009,0.00003705851,0.00000488539,0.00001370598,0.0003687589,0.00005441225,0.0007360563],"genre_scores_gemma":[0.9967751,0.0004395266,0.001181545,0.00002699656,0.000001478634,0.00001248469,0.0005181656,0.0000124722,0.001032297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001016052,"threshold_uncertainty_score":0.003399014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02362072498324339,"score_gpt":0.2653384980069503,"score_spread":0.2417177730237069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}