{"id":"W3008611307","doi":"10.1113/ep088061","title":"Low‐dose lithium feeding increases the SERCA2a‐to‐phospholamban ratio, improving SERCA function in murine left ventricles","year":2020,"lang":"en","type":"article","venue":"Experimental Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Phospholamban; SERCA; Internal medicine; Endocrinology; Heart failure; Cardiac function curve; GSK-3; Dilated cardiomyopathy; Lithium (medication); Cardiomyopathy; Chemistry; Glycogen synthase; Contractility; Medicine; ATPase; Glycogen; Kinase; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002986367,0.0006680504,0.0006543888,0.0005507027,0.0002589651,0.0005854961,0.0004073395,0.0006263464,0.001680047],"category_scores_gemma":[0.0001894412,0.0002242577,0.0005493365,0.0001722352,0.0007099197,0.000596815,0.0002093193,0.001357273,0.000360008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004551486,"about_ca_system_score_gemma":0.0003233659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00041099,"about_ca_topic_score_gemma":0.00101281,"domain_scores_codex":[0.9997912,0.00002723064,0.00003374367,0.00005331511,0.00005038573,0.00004415054],"domain_scores_gemma":[0.999737,0.00002458695,0.00009694088,0.00001963532,0.00002514538,0.00009682363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005953003,0.0001729628,0.000224425,0.0000886091,0.00001116265,0.00003735247,0.00001964095,0.00002372785,0.9967618,0.00009508164,0.00009271429,0.001877203],"study_design_scores_gemma":[0.000255093,0.003922461,0.007419412,0.00004131951,0.0001515267,0.000210542,0.0001114782,0.0006795137,0.9834545,0.0002320828,0.003499487,0.00002265541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881216,0.004179325,0.00385032,0.001058254,0.0001783534,0.00007419796,0.000924716,0.0004147154,0.001198502],"genre_scores_gemma":[0.9789879,0.004672884,0.007597581,0.0006849875,0.0001009051,0.0002670953,0.001145759,0.0001332466,0.006409506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001680047,"threshold_uncertainty_score":0.005620301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01099828532136953,"score_gpt":0.2387733110132347,"score_spread":0.2277750256918652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}