{"id":"W3008611307","doi":"10.1113/ep088061","title":"Low‐dose lithium feeding increases the SERCA2a‐to‐phospholamban ratio, improving SERCA function in murine left ventricles","year":2020,"lang":"en","type":"article","venue":"Experimental Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Phospholamban; SERCA; Internal medicine; Endocrinology; Heart failure; Cardiac function curve; GSK-3; Dilated cardiomyopathy; Lithium (medication); Cardiomyopathy; Chemistry; Glycogen synthase; Contractility; Medicine; ATPase; Glycogen; Kinase; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008690887,0.0001598329,0.00013786,0.00003780668,0.000130225,0.00002374093,0.000128539,0.0001046893,0.0001531043],"category_scores_gemma":[0.0000635293,0.0001325475,0.00006834546,0.0001375836,0.00004943514,0.00001437949,0.0001729642,0.0001069379,0.00004365616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002904052,"about_ca_system_score_gemma":0.0000305596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007402213,"about_ca_topic_score_gemma":0.00001008785,"domain_scores_codex":[0.9990079,0.00008787163,0.0002095567,0.0003816155,0.00009277103,0.00022023],"domain_scores_gemma":[0.999629,0.00001329748,0.00006590252,0.000162641,0.00003577312,0.00009341729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006390424,0.0001007735,0.0001752573,0.000009403518,0.00001378872,0.000001074869,0.0003819389,0.0008734005,0.9958467,0.00007295777,0.001403692,0.0004819119],"study_design_scores_gemma":[0.0007679826,0.0007520847,0.03259188,0.000007776322,0.000005137813,0.000005764271,0.001353587,0.001672339,0.9585787,0.0000238655,0.004062678,0.0001782201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976681,0.0003630873,0.0004460988,0.0005922982,0.0004672199,0.0002908193,0.000005140995,0.00002818173,0.0001389805],"genre_scores_gemma":[0.9958333,0.00001437331,0.00004652949,0.002803637,0.0009690571,0.00004154137,0.0001510749,0.00002109328,0.0001193832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03726807,"threshold_uncertainty_score":0.5405131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01099828532136953,"score_gpt":0.2387733110132347,"score_spread":0.2277750256918652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}