{"id":"W3008614307","doi":"10.1101/2020.02.19.953034","title":"Oxidative Modifications of Parkin Underlie its Selective Neuroprotection in Adult Human Brain","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Université de Montréal; Western University; Ottawa Hospital; University of Ottawa","funders":"","keywords":"Parkin; Neuroprotection; Neuromelanin; Dopamine; Substantia nigra; Chemistry; Biochemistry; Biology; Parkinson's disease; Neuroscience; Dopaminergic; Internal medicine; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008093514,0.0001489552,0.0001257333,0.0001494185,0.00008575686,0.0001470563,0.00006819572,0.0001499878,0.001536199],"category_scores_gemma":[0.0000842926,0.0000618737,0.00006226531,0.00006357661,0.0001494278,0.000102863,0.000104832,0.000159156,0.0002629832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001431442,"about_ca_system_score_gemma":0.00008215244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003397427,"about_ca_topic_score_gemma":0.0006394095,"domain_scores_codex":[0.9999728,0.000003587291,0.000002250696,0.000007660606,0.000006147227,0.000007417539],"domain_scores_gemma":[0.9999635,0.000003281049,0.00001379313,0.00000247103,0.000006365947,0.00001063751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005542338,0.00003923068,0.005563669,0.00009282232,0.00002477183,0.0006025964,0.00009817116,0.00008851552,0.984305,0.0002924888,0.0002920298,0.008046559],"study_design_scores_gemma":[0.00005250871,0.0006130778,0.1534215,0.00003021862,0.00007378283,0.004727066,0.0002624334,0.0009007312,0.8299094,0.001570923,0.008430207,0.000008104535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933948,0.003959948,0.001206291,0.0001101236,0.00001117998,0.00001000651,0.0001300615,0.00003270754,0.001144855],"genre_scores_gemma":[0.9973487,0.0009393002,0.000463782,0.00002367528,0.00000678215,0.0000052462,0.000134384,0.000003243583,0.001074888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001536199,"threshold_uncertainty_score":0.005139053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03141530559385253,"score_gpt":0.2649366311144363,"score_spread":0.2335213255205838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}