{"id":"W3008616613","doi":"10.1101/gad.330746.119","title":"Estrogen-related receptors are targetable ROS sensors","year":2020,"lang":"en","type":"article","venue":"Genes & Development","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute","keywords":"Biology; Oxidative stress; Reactive oxygen species; Glutamine; Cell biology; Cancer research; Pharmacology; Druggability; Mitochondrial ROS; Estrogen receptor; Biochemistry; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000107789,0.0002553975,0.0002047152,0.00003035877,0.000154211,0.00002503548,0.0001958674,0.0002627079,0.00008745048],"category_scores_gemma":[0.00003263618,0.0002348482,0.0001012968,0.0001781306,0.00004208503,0.000003971119,0.0001521869,0.0001431553,0.0003502918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002521691,"about_ca_system_score_gemma":0.0001663261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002818058,"about_ca_topic_score_gemma":0.000001004051,"domain_scores_codex":[0.9985788,0.00005929466,0.0003032588,0.0004805476,0.0001804369,0.0003976111],"domain_scores_gemma":[0.9993634,0.000005248909,0.0001126973,0.0001981727,0.00005567824,0.0002648034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001681287,0.0001111841,0.01821045,0.0000603152,0.0006697822,0.00006474252,0.000733006,0.001748533,0.9413992,0.0001319969,0.01536404,0.02133868],"study_design_scores_gemma":[0.0004126564,0.00009230493,0.0007694912,0.00001093432,0.00001856973,0.00001560361,0.0001026684,0.00006068546,0.6310561,0.000004836908,0.3671749,0.0002812436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864138,0.01152919,0.0001667164,0.0004799939,0.0003555369,0.000265167,0.000004386093,0.00007105582,0.0007141275],"genre_scores_gemma":[0.9887442,0.001308843,0.006608643,0.0007652355,0.0002432217,0.00005161285,0.0003552391,0.00007697847,0.001846015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3518108,"threshold_uncertainty_score":0.9576831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008156360700319496,"score_gpt":0.2045935107334568,"score_spread":0.1964371500331373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}