{"id":"W3008616613","doi":"10.1101/gad.330746.119","title":"Estrogen-related receptors are targetable ROS sensors","year":2020,"lang":"en","type":"article","venue":"Genes & Development","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute","keywords":"Biology; Oxidative stress; Reactive oxygen species; Glutamine; Cell biology; Cancer research; Pharmacology; Druggability; Mitochondrial ROS; Estrogen receptor; Biochemistry; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001715537,0.000358349,0.0003208031,0.0002299244,0.0001915392,0.0004650144,0.0002393443,0.0003844936,0.001927059],"category_scores_gemma":[0.00014327,0.0001582774,0.0002339609,0.0002035395,0.0002227663,0.0002693553,0.0002660631,0.0004918133,0.0008351105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002672669,"about_ca_system_score_gemma":0.0001628266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002481773,"about_ca_topic_score_gemma":0.0004497635,"domain_scores_codex":[0.9998494,0.00002704147,0.000009797322,0.00003777523,0.00004943923,0.00002644415],"domain_scores_gemma":[0.9999197,0.00001170862,0.00003536835,0.000008710259,0.00001383483,0.00001067678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002505935,0.00003393103,0.001161258,0.0003671912,0.00002758415,0.0002839786,0.00004417935,0.0002500302,0.9735866,0.002328017,0.001010351,0.02065622],"study_design_scores_gemma":[0.0000487346,0.0005610038,0.01286333,0.00006087098,0.0000715795,0.0021492,0.0001692915,0.0007252386,0.8643282,0.002258246,0.1167342,0.0000299531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7286752,0.2025074,0.03355622,0.005283025,0.0008792513,0.0001421169,0.003383816,0.000923455,0.02464945],"genre_scores_gemma":[0.9271683,0.05142946,0.006210932,0.0008751875,0.0001529617,0.00004934575,0.001138757,0.00003647953,0.01293854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001927059,"threshold_uncertainty_score":0.0064466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008156360700319496,"score_gpt":0.2045935107334568,"score_spread":0.1964371500331373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}